… This extension has provided p66ShcA with a distinct role from … Further insights into the roles
of Shc proteins in differentiation … The oncogenic effect of ShcC in neuroblastoma cells was …

… can give rise to distinct downstream signals and make unique physiological contributions. …
and terminal differentiation. During the transition, levels of ShcA decrease, whereas ShcC …

… This review focuses on these different aspects of the ALK … mutated ALK show differentiated
characteristics, a function of ALK … indicate that ShcC acts as a major docking protein in the ALK…

… Shc3 is critical for ensuring proper differentiation (6). Extensive … proliferation and significantly
inhibits neuroblastoma … The Shc3 protein has two isoforms of different sizes: 64 kDa and …

… In addition to this unique role in regulating ShcD CH1 … Neuroblastoma tumours are unique
in their capacity to spontaneously resolve in some young patients (36), yet TrkB and ShcC are …

… of cellular functions such as cell proliferation, differentiation, … such as SHC-transforming
docking protein which is further implicated … a tumor suppressor in different cancers, its role as an …

… differentiation, thus inducing the onset of neuroblastoma. … , which function as docking sites
for downstream targets [33]. … Nearly 30 different ALK fusion proteins have been described, …

… from three separate experiments (significantly different from … neuroblastoma may not affect
normal differentiated neuronal cells. Shc-C (Rai/N-Shc) is a neuronal-specific adapter protein …

… , location, degree of tumor differentiation, DNA content and different genetic alteration, among
… The mechanism of ShcC affecting the prognosis of NB may be inhibiting the differentiation …

… Thus, our results suggest that different response to hypoxia maybe due, at least in part, to …
Distinct role of ShcC docking protein in the differentiation of neuroblastoma. Oncogene 28(5)…