Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease

Y Zhang, G Reif, DP Wallace - Cellular signalling, 2020 - Elsevier
… of renal cyst development in polycystic kidney disease (PKD). … ducts, whereas the α 6 -subunit
is expressed in all nephron … 1 -subunit in precystic and cystic collecting duct cells in fetal

Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease

A Raman, GA Reif, Y Dai, A Khanna, X Li… - Journal of the …, 2017 - journals.lww.com
… , and enlarged kidneys. Several signaling pathways have been implicated in polycystic
kidney disease (PKD) 2 ; however, the mechanisms involved in disease progression remain …

[HTML][HTML] Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

X Zhou, VE Torres - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
… specific expression of constitutively active AMPK, with a gain-of-function mutation in the
AMPKγ1 subunit, resulted in an early-onset polycystic kidney phenotype with collecting duct cysts…

THE ROLE OF MATRICELLULAR SIGNALING IN POLYCYSTIC KIDNEY DISEASE

A Raman - 2017 - kuscholarworks.ku.edu
Polycystic kidney disease (PKD) is characterized by excessive enlargement of the kidney, due
to the hyperplastic growth of renal … It is speculated that breakdown of matrix molecules can …

Collagen type XI alpha 1 (COL11A1): a novel biomarker and a key player in cancer

S Nallanthighal, JP Heiserman, DJ Cheon - Cancers, 2021 - mdpi.com
… terminal domain (NTD) of COL11A1 in fetal bovine cartilage, which is displayed at the …
integrin heterodimers (alpha integrin subunits α1, α2, α10, α11 paired with the β1 integrin subunit), …

Proteomics of Serum Samples for the Exploration of the Pathological Mechanism of Obstetric Antiphospholipid Syndrome

Y Zhang, S Jin, W Tian, D Shi, Y Chen… - Journal of Proteome …, 2023 - ACS Publications
… (OAPS) is a multisystem disorder characterized by thrombosis or recurrent fetal loss. In this
… KEGG pathways related to autoimmune diseases, allergic diseases, and pathogen infection. …

[HTML][HTML] The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis

AT Phillips, EF Boumil, A Venkatesan… - European journal of cell …, 2023 - Elsevier
… due to protein cleavage/breakdown. To assess the level of … subunits (β1 and β5), we tested
how DAAM1 siRNA altered integrin ubiquitin status. For both β1 and β5-integrin subunits, we …

The pig as a model for immunology research

R Pabst - Cell and tissue research, 2020 - Springer
… be optimal when the organ distribution and age dependence … However, Intrauterine injection
of fetal and germfree pigs with … The alpha integrin C11R1 was most frequently expressed. …

Daam1 negatively regulates USP10 activity

AT Phillips, EF Boumil, A Venkatesan, N Castro… - bioRxiv, 2022 - biorxiv.org
… We predicted that a random distribution of Daam1 and USP10 … Thus, Daam1 transitioned
from a distribution that was, on … in HCFs, we analyzed integrin subunit protein levels without or …

Ecam and tyrosine kinases expression profiling of canine & feline naturally occurring soft tissue sarcomas and 3-mca induced sarcomas in mice treated with …

I Ahmed - 2018 - acikbilim.yok.gov.tr
… There exist 18 α and 8 subunits whose combinations can generate 24 different receptors
having a different affinity and tissue distribution (Hynes, 2002; Takada et al., 2007; Barczyk et al.…