Association of protein distribution and gene expression revealed by PET and post-mortem quantification in the serotonergic system of the human brain
A Komorowski, GM James, C Philippe… - Cerebral …, 2017 - academic.oup.com
… Besides the main inhibitory (5-HT 1A ) and excitatory (5-HT 2A ) serotonin receptors as well
as the … Given the different pharmacological possibilities to influence these targets further …
as the … Given the different pharmacological possibilities to influence these targets further …
Change in Expression of 5-HT 6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F] 2FNQ1P
P Courault, S Emery, S Bouvard, F Liger… - Journal of …, 2020 - content.iospress.com
… is one of the most recently identified serotonin receptors in … identified, first in rat [3,4] and
then in the human brain [5]. The … the pharmacological hypothesis that 5-HT 6 receptor blockade …
then in the human brain [5]. The … the pharmacological hypothesis that 5-HT 6 receptor blockade …
Preclinical validation of [18F] 2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue
S Emery, S Fieux, B Vidal, P Courault… - Nuclear Medicine and …, 2020 - Elsevier
… Serotonin receptor subtype-6 of (5-HT 6 ) is one of the more … a pharmacological profile suitable
for in-vivo study in humans. … for studying 5-HT 6 receptor density and distribution in animal …
for in-vivo study in humans. … for studying 5-HT 6 receptor density and distribution in animal …
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain
I Muneta‐Arrate, P Miranda‐Azpiazu… - … of Pharmacology, 2024 - Wiley Online Library
… Even so, if that possibility was true and 5-HT was present, drugs … relative efficacy at serotonin
type 2A and 2C receptors: Evidence for … The pharmacology and distribution of human 5-…
type 2A and 2C receptors: Evidence for … The pharmacology and distribution of human 5-…
Serotonin type 6 and 7 receptors as a novel therapeutic target for the treatment of schizophrenia
EW Tsegay, DG Demise, NA Hailu… - … Disease and Treatment, 2020 - Taylor & Francis
… and pharmacological differences serotonin receptors (5-… brain areas with higher distribution
of 5-HT 6 and 7 receptors … HT7Rs at prefrontal cortex in post mortem studies of schizophrenic …
of 5-HT 6 and 7 receptors … HT7Rs at prefrontal cortex in post mortem studies of schizophrenic …
Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer's disease: a post-mortem study with PET radiopharmaceuticals
B Vidal, J Sebti, M Verdurand, S Fieux, T Billard… - …, 2016 - Elsevier
… Serotonergic 5-HT 1A receptors are of particular interest since … their pharmacological profile.
Indeed, as G-protein-coupled … of 5-HT 1A receptor coupling in human brain during AD, using …
Indeed, as G-protein-coupled … of 5-HT 1A receptor coupling in human brain during AD, using …
Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
R Diez-Alarcia, C Muguruza, G Rivero… - Translational …, 2021 - nature.com
… The status of serotonin 5HT 2A receptors (5HT 2A Rs) in … This study investigates 5HT 2A R
density in the post-mortem … agonist properties on 5HT 2A Rs in post-mortem human brain 13,…
density in the post-mortem … agonist properties on 5HT 2A Rs in post-mortem human brain 13,…
Alterations of expression of the serotonin 5-HT4 receptor in brain disorders
H Rebholz, E Friedman, J Castello - International Journal of Molecular …, 2018 - mdpi.com
… , confirming data stemming from post-mortem tissue and … knowledge of 5-HT 4 R expression
in brain regions relevant to … use of 5-HT 4 R pharmacological tools and shows that 5-HT 4 …
in brain regions relevant to … use of 5-HT 4 R pharmacological tools and shows that 5-HT 4 …
A neuropharmacological study of 5-HT4 and 5-HT6 receptors and their relevance to Alzheimer's disease
WS Sarawi - 2019 - etheses.bham.ac.uk
… the regulation of 5-HT neurotransmission and its relation to the … of NFTs in post-mortem
cortices of AD patients was … Most of the serotonin receptors are reduced in the AD brains, and …
cortices of AD patients was … Most of the serotonin receptors are reduced in the AD brains, and …
Expression of serotonin 2A, 2C, 6 and 7 receptor and IL-6 mRNA in experimental toxoplasmic encephalitis in mice
HT Atmaca - Heliyon, 2019 - cell.com
… expression profile of those 5-HT receptors in mice on an … on rare occasions after routine
post-mortem investigations. In … physiological, neuroanatomical, pharmacological, biochemical, …
post-mortem investigations. In … physiological, neuroanatomical, pharmacological, biochemical, …