… identified panel of small molecule inhibitors of BAF (BAFi's) for potential to activate latent
HIV-1… transcriptionally silencing the latent reservoir are likely to be diverse and heterogeneous. …

… line of HIV-1 latency to screen a library of structurally diverse, … pathways, to identify inhibitors
of HIV-1 latency reversal. The … by small molecule agonists/antagonists (8). For example, the …

… Here we report a high-throughput screen for inhibitors of BAF-mediated transcription in cells
and the subsequent identification of … Through this mechanism, these compounds are able to …

… LRAs compared to synthetic small molecule libraries, where … , while treatment with
compounds acting through similar … novel HIV inhibitors from this chemically-diverse library (eg, […

… identified in the medicinal plant Homalanthus nutans from Samoa (34). Prostratin induces
proviral transcription in a variety of HIV-1 latency … cure of HIV-1 infection through eradication of …

… agents from the ZINC15 database (118 identified) and screening of 200,000 other small
molecules (22 identified) [98]. … A recent study using 418 structurally diverse, cell-permeable, and …

… diversity within the latent and reactivated reservoirs, the patient-to-… of HIV-1 expression is
mediated through a plethora of … been found to be lower in resting CD4 + T cells harboring latent …

… The concept of eliminating latently infected CD4 + T cells through activating HIV-1 from latency
… For example, when plasma HIV-1 RNA is detected in the 100 copies/mL range following …

… through viral cytopathic effects. A variety of LRAs have been tested for their ability to reactivate
… combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+…

… We found significant differences in HDACi cytotoxicity … Our findings indicate that these small
molecules induce no … Our studies suggest that different classes of LRAs have diverse impact …