… -null HSCs can regenerate over at least 12 transplant generations in mice, far exceeding the
lifespan of normal HSCs. Molecular characterization reveals that this in vivo immortalization …

… Here, we investigated the impact of conditional hematopoietic Dnmt3a loss on disease …
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. …

… a tight balance between the hematopoietic stem cell (HSC) … over normal HSCs and may
predispose to the acquisition of … 8) in Dnmt3a −/− HSCs drive malignant transformation. Although …

… poised to transform owing to a limited number of predisposing … thought of as a disease of
hematopoietic stem cells (HSC), in … solid arrows) until malignant transformation (indicated with …

… DNMT3A loss in hematopoietic stem cells (HSCs) has been … We have shown that the loss of
DNMT3A in the mouse can … of the Idh2 mutant promote malignant transformation, we focused …

… negative loss of DNMT3A methylation activity, but 15% of DNMT3A … described constitutive
Dnmt3a-knockout mouse with a … the hematopoietic stem/progenitor cells (HSPCs) of Dnmt3a +…

… These results indicate that Dnmt3a loss alone preserves the stem cell program but, in …
development of malignancies with TET2 and DNMT3A co-mutation in mouse and human. …

… We show in mouse models that Dnmt3a loss-of-function co-operates with Notch1 gain-of-function …
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. …

… in DNMT3A, TET2, and ASXL1 in hematopoietic stem cell … Tet2-silenced murine BM
hematopoietic stem/progenitor cells (… B-cell malignancies, and Tet2 loss combined with Dnmt3a …

… loss of DNMT3A function is important for the development of T-… Ezh2 loss in HSC predisposed
mice to develop … regulators in various types of malignant stem cells, EZH2 inhibitors can …