Role of striatal dopamine signaling in compulsive eating associated with obesity

RM O'Connor, PJ Kenny - Current Opinion in Behavioral Sciences, 2016 - Elsevier
… Similar addiction-like food seeking behaviors that are resistant to punishment have also …
to earn food by overweight rats also coincides with marked deficits in brain reward function, …

Reward sensitivity deficits in a rat model of compulsive eating behavior

CF Moore, MZ Leonard, NM Micovic… - …, 2020 - nature.com
… of obesity and binge eating have observed downregulated DA signaling, lower DA turnover,
and reduced activity of the dopamine … these dual components in an addiction-like disorder. …

The role of reward circuitry and food addiction in the obesity epidemic: An update

SJ Leigh, MJ Morris - Biological psychology, 2018 - Elsevier
binge eating. Where examined, the prevalence of addiction-like behaviour in overweight and
obese … baseline D2 receptor expression in the NAc while obesity-prone rats have increased …

Linking the Features of Food Addiction and Drug Addiction: A New Narrative of Dopamine D2 Receptors and Beyond

PG Brasiel, SCPD Luquetti - … of Substance Misuse and Addictions: From …, 2022 - Springer
… , obesity with compulsive eating behaviors involves reward circuitry … the reward system,
promotes addiction-like eating, and … in obese rats: role for dopamine D2 receptors. Nat Neurosci …

Repeated binge‐like eating episodes in female rats alter adenosine A2A and dopamine D2 receptor genes regulation in the brain reward system

F Mercante, E Micioni Di Bonaventura… - … Journal of Eating …, 2024 - Wiley Online Library
… in the nucleus accumbens in bingeeating rats. Concurrently, site-… of this psychiatric disorder
and developing effective inter- … and striatopallidal transmission in addiction and obesity. …

Addiction-like synaptic impairments in diet-induced obesity

RM Brown, YM Kupchik, S Spencer, C Garcia-Keller… - Biological …, 2017 - Elsevier
… may be explained by dysfunctions in reward circuitry. Indeed, … rats prone to obesity due to
excessive intake of palatable … in binge eating disorder (29) and in individuals classified as …

Neuropharmacology of compulsive eating

CF Moore, JI Panciera, V Sabino… - … Transactions of the …, 2018 - royalsocietypublishing.org
… -fat diet, obese rats also exhibited compulsive eating behaviour … of rats prior to high-fat diet
access worsened reward deficits … - opioid system dysfunction in the PFC in compulsive eating, …

Reward deficits in compulsive eating

PJ Kenny - Compulsive Eating Behavior and Food Addiction, 2019 - Elsevier
… systems and the role that such diet-induced reward dysfunction may play in … obese rats
will consume palatable food in a compulsive-liked manner and if striatal dopamine D2 receptor

Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens

NL Wei, ZF Quan, T Zhao, XD Yu, Q Xie… - Neuropsychiatric …, 2019 - Taylor & Francis
… their binge eating behaviors, cravings for palatable food, … In order to induce food addiction-like
behaviors, we applied a fat… to ultrasonic rat repellent to model compulsive eating behaviors…

Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats–possible relevance in the psychopathology and treatment of binge-eating …

DJ Heal, M Hallam, M Prow, J Gosden… - Journal of …, 2017 - journals.sagepub.com
… to indicate that attention deficit hyperactivity disorder (ADHD) … of dietary-induced obesity
in female, Wistar rats in which they … While there is evidence that underactive reward systems …