[PDF][PDF] Dose-related reductions in blood pressure with a RNA interference (RNAi) therapeutic targeting angiotensinogen in hypertensive patients: interim results from a …
S Desai - Circulation, 2020 - academia.edu
S Desai
Circulation, 2020•academia.edu… • No patient has required intervention for low blood pressure • No clinically significant
elevations in serum ALT, serum creatinine, or serum potassium • 5 patients with injection
site reactions, all mild and transient … Maximum reductions of 19 mm Hg for systolic BP and
12 mm Hg for diastolic BP observed in individual patients after 200 mg dose … • BP
reductions mirror AGT knockdown, with >10 mm Hg reduction in 24h SBP observed at 8
weeks after single doses of 100 mg or higher …
elevations in serum ALT, serum creatinine, or serum potassium • 5 patients with injection
site reactions, all mild and transient … Maximum reductions of 19 mm Hg for systolic BP and
12 mm Hg for diastolic BP observed in individual patients after 200 mg dose … • BP
reductions mirror AGT knockdown, with >10 mm Hg reduction in 24h SBP observed at 8
weeks after single doses of 100 mg or higher …
BACKGROUND
Hypertension remains the leading cause of death and disability-adjusted life-years worldwide1–4…
academia.edu
以上显示的是最相近的搜索结果。 查看全部搜索结果