[HTML][HTML] Synthesis of Novel Suramin Analogs With Anti-Proliferative Activity via FGF1 and FGFRD2 Blockade
… show potential as novel therapeutic agents for their anti-… of suramin was understood, less
toxic and more specific new … , suramin has been tested for NSCLC’s, prostate cancer, and …
toxic and more specific new … , suramin has been tested for NSCLC’s, prostate cancer, and …
Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies
… are needed to explore its potential as a therapeutic agent. … In colorectal cancer, theobromine
was able to induce … , and its potential toxicity, ADMET prediction offers valuable insights into …
was able to induce … , and its potential toxicity, ADMET prediction offers valuable insights into …
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
… The C-terminal region has two highly conserved motifs: a nucleotidyltransferase (NTase) …
/translocation was rarely observed in some human colon cancer cell lines. This study indicated …
/translocation was rarely observed in some human colon cancer cell lines. This study indicated …
Drug repositioning: Progress and challenges in drug discovery for various diseases
Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
… that there are two types of lesions in the brain of AD patients, … Colorectal cancer is the second
leading cause of cancer … time and cost but also has very high safety and toxicity risk [135]…
leading cause of cancer … time and cost but also has very high safety and toxicity risk [135]…
Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery
H Zhang, Q Zhang, J Tu, Q You, L Wang - European Journal of Medicinal …, 2023 - Elsevier
… , which leads to colorectal cancer cell development. (E) In AD … Recently, new applications
of suramin were gradually being … to PPP5C while reducing toxicity remains a challenge. …
of suramin were gradually being … to PPP5C while reducing toxicity remains a challenge. …
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
… therapy can increase the sensitivity of colorectal cancer cells by … provides a new treatment
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …
Urea derivatives in modern drug discovery and medicinal chemistry
AK Ghosh, M Brindisi - Journal of medicinal chemistry, 2019 - ACS Publications
… of suramin (4) with potent antitrypanosomal properties. … Alternative routes involving reactions
of amines with less toxic agents … colon cancer) and HCT116/VM46 (resistant human colon …
of amines with less toxic agents … colon cancer) and HCT116/VM46 (resistant human colon …
[HTML][HTML] P2RX7 purinoceptor as a therapeutic target—the second coming?
CNJ Young, DC Górecki - Frontiers in chemistry, 2018 - frontiersin.org
… lead to the development of new, less toxic anticancer treatments. … cell death has been
suggested in embryonic neural … This tuning mechanism allows malignant cells to profit from …
suggested in embryonic neural … This tuning mechanism allows malignant cells to profit from …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
… provide … neuronal cells, from hepatocytes to adipose cells have further shown the exquisite
role of HuR in regulating many aspects of cellular differentiation and functions in various cell …
role of HuR in regulating many aspects of cellular differentiation and functions in various cell …
Current screening methodologies in drug discovery for selected human diseases
… paper provides a comprehensive overview of screening … investigating the antimicrobial
interaction between two drugs [33]. … more sensitive, less time consuming and not as toxic as, for …
interaction between two drugs [33]. … more sensitive, less time consuming and not as toxic as, for …