[HTML][HTML] Synthesis of Novel Suramin Analogs With Anti-Proliferative Activity via FGF1 and FGFRD2 Blockade

N Parveen, YL Lin, RH Chou, CM Sun, C Yu - Frontiers in Chemistry, 2022 - frontiersin.org
… show potential as novel therapeutic agents for their anti-… of suramin was understood, less
toxic and more specific new … , suramin has been tested for NSCLC’s, prostate cancer, and …

Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies

IH Eissa, RG Yousef, H Elkady, EB Elkaeed… - … -Research and Practice, 2023 - Elsevier
… are needed to explore its potential as a therapeutic agent. … In colorectal cancer, theobromine
was able to induce … , and its potential toxicity, ADMET prediction offers valuable insights into …

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

JK Seok, M Kim, HC Kang, YY Cho, HS Lee… - Archives of Pharmacal …, 2023 - Springer
… The C-terminal region has two highly conserved motifs: a nucleotidyltransferase (NTase) …
/translocation was rarely observed in some human colon cancer cell lines. This study indicated …

Drug repositioning: Progress and challenges in drug discovery for various diseases

Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
… that there are two types of lesions in the brain of AD patients, … Colorectal cancer is the second
leading cause of cancer … time and cost but also has very high safety and toxicity risk [135]…

Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery

H Zhang, Q Zhang, J Tu, Q You, L Wang - European Journal of Medicinal …, 2023 - Elsevier
… , which leads to colorectal cancer cell development. (E) In AD … Recently, new applications
of suramin were gradually being … to PPP5C while reducing toxicity remains a challenge. …

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
therapy can increase the sensitivity of colorectal cancer cells by … provides a new treatment
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …

Urea derivatives in modern drug discovery and medicinal chemistry

AK Ghosh, M Brindisi - Journal of medicinal chemistry, 2019 - ACS Publications
… of suramin (4) with potent antitrypanosomal properties. … Alternative routes involving reactions
of amines with less toxic agentscolon cancer) and HCT116/VM46 (resistant human colon

[HTML][HTML] P2RX7 purinoceptor as a therapeutic target—the second coming?

CNJ Young, DC Górecki - Frontiers in chemistry, 2018 - frontiersin.org
… lead to the development of new, less toxic anticancer treatments. … cell death has been
suggested in embryonic neural … This tuning mechanism allows malignant cells to profit from …

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
provideneuronal cells, from hepatocytes to adipose cells have further shown the exquisite
role of HuR in regulating many aspects of cellular differentiation and functions in various cell

Current screening methodologies in drug discovery for selected human diseases

OM Lage, MC Ramos, R Calisto, E Almeida… - Marine drugs, 2018 - mdpi.com
… paper provides a comprehensive overview of screening … investigating the antimicrobial
interaction between two drugs [33]. … more sensitive, less time consuming and not as toxic as, for …