Glycosyl and alkyl modifications on potential therapeutic drugs targeting parasitic, cancer and neurodegenerative diseases

E Belmonte Reche - 2018 - digibug.ugr.es
… the commonly used drugs used to treat the disease such as Suramin and … toxic in cancer
cells than the aglycone and 6 times less toxic in mice.[110] 18fluoro-2-deoxyglucose (FDG) has

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
provideneuronal cells, from hepatocytes to adipose cells have further shown the exquisite
role of HuR in regulating many aspects of cellular differentiation and functions in various cell

Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance

JQ Wang, Y Yang, CY Cai, QX Teng, Q Cui, J Lin… - Drug Resistance …, 2021 - Elsevier
… The whole structure of MRP1, three TMDs with two NBDs, forms a stable network to ensure
… coupled to ATP hydrolysis which provides the required energy to expel substrate drugs to the …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: a decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
… Therefore, despite the existence of several therapeutic drugslow toxicity on HAF (normal
human fibroblasts). The … as a DNA interactive cytotoxic representative for colon cancer therapy. …

[PDF][PDF] Design, synthesis and biological evaluation of novel bioactive molecules for the treatment of protozoan and human diseases

C DI CHIO, R ETTARI, P DUGO - 2021 - iris.unime.it
… Since our research group has been actively involved in the … Suramin is the first discovered
drug, it is an ureidic derivative with a … is to obtain a lower toxicity and reduced side effects. …

Drug Repurposing Patent Applications July–September 2022

HAM Mucke - ASSAY and Drug Development Technologies, 2022 - liebertpub.com
… in human THP-1 AML and HCT116 colon cancer cell lines … of lipofuscin-like granules into
a less toxic form. For the peer-… protease, 3CL pro , by suramin and quinacrine, 27 have made …

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
therapy can increase the sensitivity of colorectal cancer cells by … provides a new treatment
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …

[HTML][HTML] Coumarins and coumarin-related compounds in pharmacotherapy of cancer

E Küpeli Akkol, Y Genç, B Karpuz, E Sobarzo-Sánchez… - Cancers, 2020 - mdpi.com
… due to their low toxicity, low drug resistance, low cost and … used as preventive and therapeutic
agents in cancer therapy. These … In this study, it has been shown that esculetin provides a …

… -N′-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

M Schnekenburger, E Goffin, JY Lee… - Journal of medicinal …, 2017 - ACS Publications
… selective toxicity between normal astrocytes and glioma cells … Since the simultaneous
inhibition of SIRT1 and -2 has been … The human colon cancer cell line HCT116 p53 wild-type and …

[HTML][HTML] Identification of drugs that restore primary cilium expression in cancer cells

NA Khan, N Willemarck, A Talebi, A Marchand… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… models, has been reported as a potential anti-tumor agent due … , stability, toxicity etc., which
form bottlenecks in the therapeutic … between two groups were assessed using the t-test. To …