Glycosyl and alkyl modifications on potential therapeutic drugs targeting parasitic, cancer and neurodegenerative diseases
E Belmonte Reche - 2018 - digibug.ugr.es
… the commonly used drugs used to treat the disease such as Suramin and … toxic in cancer
cells than the aglycone and 6 times less toxic in mice.[110] 18fluoro-2-deoxyglucose (FDG) has …
cells than the aglycone and 6 times less toxic in mice.[110] 18fluoro-2-deoxyglucose (FDG) has …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
… provide … neuronal cells, from hepatocytes to adipose cells have further shown the exquisite
role of HuR in regulating many aspects of cellular differentiation and functions in various cell …
role of HuR in regulating many aspects of cellular differentiation and functions in various cell …
Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
… The whole structure of MRP1, three TMDs with two NBDs, forms a stable network to ensure
… coupled to ATP hydrolysis which provides the required energy to expel substrate drugs to the …
… coupled to ATP hydrolysis which provides the required energy to expel substrate drugs to the …
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: a decade update
K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
… Therefore, despite the existence of several therapeutic drugs… low toxicity on HAF (normal
human fibroblasts). The … as a DNA interactive cytotoxic representative for colon cancer therapy. …
human fibroblasts). The … as a DNA interactive cytotoxic representative for colon cancer therapy. …
[PDF][PDF] Design, synthesis and biological evaluation of novel bioactive molecules for the treatment of protozoan and human diseases
… Since our research group has been actively involved in the … Suramin is the first discovered
drug, it is an ureidic derivative with a … is to obtain a lower toxicity and reduced side effects. …
drug, it is an ureidic derivative with a … is to obtain a lower toxicity and reduced side effects. …
Drug Repurposing Patent Applications July–September 2022
HAM Mucke - ASSAY and Drug Development Technologies, 2022 - liebertpub.com
… in human THP-1 AML and HCT116 colon cancer cell lines … of lipofuscin-like granules into
a less toxic form. For the peer-… protease, 3CL pro , by suramin and quinacrine, 27 have made …
a less toxic form. For the peer-… protease, 3CL pro , by suramin and quinacrine, 27 have made …
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
… therapy can increase the sensitivity of colorectal cancer cells by … provides a new treatment
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …
for metabolic syndrome, cell … 11 was superior in terms of toxicity and specificity problems, and …
[HTML][HTML] Coumarins and coumarin-related compounds in pharmacotherapy of cancer
… due to their low toxicity, low drug resistance, low cost and … used as preventive and therapeutic
agents in cancer therapy. These … In this study, it has been shown that esculetin provides a …
agents in cancer therapy. These … In this study, it has been shown that esculetin provides a …
… -N′-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines
M Schnekenburger, E Goffin, JY Lee… - Journal of medicinal …, 2017 - ACS Publications
… selective toxicity between normal astrocytes and glioma cells … Since the simultaneous
inhibition of SIRT1 and -2 has been … The human colon cancer cell line HCT116 p53 wild-type and …
inhibition of SIRT1 and -2 has been … The human colon cancer cell line HCT116 p53 wild-type and …
[HTML][HTML] Identification of drugs that restore primary cilium expression in cancer cells
NA Khan, N Willemarck, A Talebi, A Marchand… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… models, has been reported as a potential anti-tumor agent due … , stability, toxicity etc., which
form bottlenecks in the therapeutic … between two groups were assessed using the t-test. To …
form bottlenecks in the therapeutic … between two groups were assessed using the t-test. To …