Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents
… in BC cells compared with lung and colon cancer cells. HDAC6 … Combination treatment of
suramin and DNA methyltransferase … , identification of new selective HDACi with low toxicity, …
suramin and DNA methyltransferase … , identification of new selective HDACi with low toxicity, …
[HTML][HTML] Drug delivery approaches for HuR-targeted therapy for lung cancer
… that prevent their maximal exploitation as cancer therapies. To address this, in the conclusion
of this review, we provide a list of nanomedicine-… Malignant peripheral nerve sheath tumors …
of this review, we provide a list of nanomedicine-… Malignant peripheral nerve sheath tumors …
[HTML][HTML] Bibenzyls and bisbybenzyls of bryophytic origin as promising source of novel therapeutics: pharmacology, synthesis and structure-activity
S Nandy, A Dey - DARU Journal of Pharmaceutical Sciences, 2020 - Springer
… of biologically active, toxic, allelopathic secondary metabolites … therapeutic standard drugs
eflornithine and suramin [62]. … potential as new therapeutic agent in influenza A inhibition [1]. …
eflornithine and suramin [62]. … potential as new therapeutic agent in influenza A inhibition [1]. …
[HTML][HTML] Dual tumor suppressor and tumor promoter action of sirtuins in determining malignant phenotype
V Carafa, L Altucci, A Nebbioso - Frontiers in pharmacology, 2019 - frontiersin.org
… cells that undergo further differentiation into epithelial cells, and … with the progression and
recurrence of colorectal cancer. … However, its neurologic toxicity has limited its use in the clinic…
recurrence of colorectal cancer. … However, its neurologic toxicity has limited its use in the clinic…
[HTML][HTML] FGF/FGFR-dependent molecular mechanisms underlying anti-cancer drug resistance
J Szymczyk, KD Sluzalska, I Materla, L Opalinski… - Cancers, 2021 - mdpi.com
… -resistant colon carcinoma cells on endothelial cells growth [… effect of suramin (at non-toxic
doses) on tumor sensitization to … The reduced responses to therapeutic agents have been …
doses) on tumor sensitization to … The reduced responses to therapeutic agents have been …
[HTML][HTML] Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer
SD Pramanik, A Kumar Halder, U Mukherjee… - Frontiers in …, 2022 - frontiersin.org
… or chemotherapy require newer therapeutic agents. By improving the … cancer cells in 2006,
compared to lung and colon cancer … inhibitors such sirtinol, cambinol, EX527, and suramin. By …
compared to lung and colon cancer … inhibitors such sirtinol, cambinol, EX527, and suramin. By …
Targeting the RNA-binding protein HuR in cancer
… inhibitors of translocation may be less toxic through … gene in human colon cancer cells
under oxidative stress. Mol … Suramin, screened from an approved drug library, inhibits HuR …
under oxidative stress. Mol … Suramin, screened from an approved drug library, inhibits HuR …
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations
… was able to induce apoptosis in colorectal cancer [28] and to … were found to have a low
toxicity profile based on the in silico … receptor antagonists suramin and theobromine on tumor-…
toxicity profile based on the in silico … receptor antagonists suramin and theobromine on tumor-…
Recent advances in novel drug delivery systems and approaches for management of breast cancer: A comprehensive review
… Silica NPs loaded with dual drugs (PTX and suramin) using … MCF-7 BC cells and human
colorectal cancer cells [155] … Micelles are a therapeutic agent or a carrier to deliver a poorly …
colorectal cancer cells [155] … Micelles are a therapeutic agent or a carrier to deliver a poorly …
Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity
ZS Wu, CF Liu, B Fu, RH Chou, C Yu - Biochemical and biophysical …, 2016 - Elsevier
… The WST1 assay is more sensitive and has lower cellular toxicity … 3D shows suramin
localized at two hFGF1-binding sites: the … for synthesizing the derivatives of suramin and greatly …
localized at two hFGF1-binding sites: the … for synthesizing the derivatives of suramin and greatly …