[HTML][HTML] β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios

CM Ribeiro, EJR Silva, BT Hinton… - Asian journal of …, 2016 - journals.lww.com
… and region-specific changes occur in the expression of the β-defensin Spag11c gene as the
rat … the dynamic changes of the spatio-temporal expression of SPAG11C in the developing

Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis

CM Ribeiro, LGA Ferreira, DS Thimoteo… - Molecular and Cellular …, 2017 - Elsevier
… the spatio-temporal expression of the β-defensin SPAG11C … in vivo Spag11c mRNA changes
in the developing WDs cited … The dynamic modulation of SPAG11C expression at mRNA …

The Physiological Functions of Beta-defensin 19/119 in the Male Reproductive Tract

J Jin - 2021 - search.proquest.com
development of germ cells and the microbiome of the MRT. … to investigate the dynamics
of microbiota or changes in its … showed that β-defensin DEFB119 specifically expressed in …

[HTML][HTML] Crucial convolution: Genetic and molecular mechanisms of coiling during epididymis formation and development in embryogenesis

J Wong, J Gasperoni, J Fuller, SVH Grommen… - Journal of …, 2022 - mdpi.com
SPAG11C is an androgen-regulated β-defensin required for Wolffian duct coiling, however,
epithelial AR signalling has been shown to be non-essential for coiling. WNT signalling has …

β-Defensins: Antimicrobial Peptides at the Intersection of Immunity and Male Fertility

V Batra, A Kumaresan, R Kumar, TK Datta - Current Concepts in Bovine …, 2022 - Springer
… BD gene expression in the MRT in a Spatio-temporal manner (… expression levels of BDs like
Spag11a (Bin1b) and Spag11c … genome controls the expression of β-defensin genes would …

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

SH Leir, S Yin, JL Kerschner, W Cosme… - Life science …, 2020 - life-science-alliance.org
… The B form of SPAG11 contains a C-terminal β-defensin domain which is lacking from the A
… gene expression signature than those in cluster 0: although other members of the β defensin

Epididymal embryonic development harbors TLR4/NFKB signaling pathway as a morphogenetic player

LGA Ferreira, FA Nishino, SG Fernandes… - Journal of Reproductive …, 2022 - Elsevier
… (coiled duct) WDs, and spatio-temporal changes in TLR4 … We have shown that β-defensin
SPAG11C (sperm associated … that regulates both the dynamic remodeling of ECM components…

[HTML][HTML] Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

A Denadai-Souza, CM Ribeiro, C Rolland… - Arthritis Research & …, 2017 - Springer
… that the rat β-defensin SPAG11C, the ortholog of the human SPAG11B isoform C, hSPAG11B/C,
is expressed in articular chondrocytes during the male rat embryonic development [22]. …

Functions of antimicrobial peptides in vertebrates

E Edilia Avila - Current Protein and Peptide Science, 2017 - ingentaconnect.com
β-defensin 1 (hBD-1) is expressed in epithelial cells in the … against fungi is an extensive and
dynamic research area, as reviewed … development [381]. The interactions between human …

[HTML][HTML] Identification of new epididymal luminal fluid proteins involved in sperm maturation in infertile rats treated by dutasteride using iTRAQ

SW Xie, GT Li, LJ Qu, Y Cao, Q Wang, JY Zhou… - Molecules, 2016 - mdpi.com
Background: Spermatozoa become mature and acquire fertilizing capacity during their
passage through the epididymal lumen. In this study, we identified new epididymal luminal fluid …