ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition
… Indeed, to our knowledge, the only growth factor known to induce EMT in lens epithelial
cells is TGFβ. It is therefore intriguing to discover that TGFβ is somehow utilizing …
cells is TGFβ. It is therefore intriguing to discover that TGFβ is somehow utilizing …
[HTML][HTML] Role of COX-2/PGE2 mediated inflammation in oral squamous cell carcinoma
WHS Nasry, JC Rodriguez-Lecompte, CK Martin - Cancers, 2018 - mdpi.com
… induction of OSCC apoptosis and reduced proliferation along with inhibition of the COX-2/PGE2/EGFR
pathway [… intercellular adhesion molecule in epithelial cells and has a critical role …
pathway [… intercellular adhesion molecule in epithelial cells and has a critical role …
[PDF][PDF] Effect of TGF-β1 on apoptosis of colon cancer cells via the ERK signaling pathway
Y Zhao, S Xia, C Cao, X Du - J BUON, 2019 - jbuon.com
… The role of ERK in the ROSinduced inhibition of COX-2 in colon cancer cells … EGFR
signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells…
signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells…
COX-2 in liver fibrosis
H Yang, Y Xuefeng, W Shandong, X Jianhua - Clinica chimica acta, 2020 - Elsevier
… epidermal growth factor receptor (EGFR) pathway [39]. However… of fibrotic epithelial-
mesenchymal transition in human lung … induction of COX-2 in non-targeted bronchial epithelial …
mesenchymal transition in human lung … induction of COX-2 in non-targeted bronchial epithelial …
WISP1 induces the expression of macrophage migration inhibitory factor in human lung fibroblasts through Src kinases and EGFR-activated signaling pathways
ME Christopoulou, SS Skandalis… - … of Physiology-Cell …, 2024 - journals.physiology.org
… airway inflammation in COPD by promoting the production of 62 inflammatory cytokines via
a PPARδ/p38 signalling pathway in airway epithelial cells … of WISP1 to induce COX‐2, IL‐6 …
a PPARδ/p38 signalling pathway in airway epithelial cells … of WISP1 to induce COX‐2, IL‐6 …
[HTML][HTML] Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas
J Wang, K Zou, X Feng, M Chen, C Li, R Tang, Y Xuan… - Molecular cancer, 2017 - Springer
… NMI induced apoptosis, suppressed lung cancer cell growth … growth factor receptor (EGFR)
mutations and echinoderm … the NMI/COX-2 signaling pathways in lung adenocarcinoma …
mutations and echinoderm … the NMI/COX-2 signaling pathways in lung adenocarcinoma …
COX-2 signaling in the tumor microenvironment
Y Zhang, S Tighe, YT Zhu - Tumor Microenvironment: Molecular Players …, 2020 - Springer
… For example, EGFR transactivation mediated by intracellular … of COX-2 might regulate the
intrinsic apoptosis signaling by … apoptosis induced by butyrate in rat intestinal epithelial cells […
intrinsic apoptosis signaling by … apoptosis induced by butyrate in rat intestinal epithelial cells […
[HTML][HTML] Mechanistic understanding of curcumin's therapeutic effects in lung cancer
… It was indicated that human lung adenocarcinoma H441 cells are sensitive to curcumin …
that the COX-2 product, prostaglandin E 2 (PGE 2 ), is able to transactivate the EGFR pathway …
that the COX-2 product, prostaglandin E 2 (PGE 2 ), is able to transactivate the EGFR pathway …
[HTML][HTML] Pancreatic adenocarcinoma therapeutics targeting RTK and TGF beta receptor
HH Yang, JW Liu, JH Lee, HJ Harn… - International journal of …, 2021 - mdpi.com
… transduction pathways, such as growth-factor induced … of COX-2 was activated by
EGFR/p38-MAPK/Sp1 signaling axis … In normal tissues, TGFβ signaling leaves the epithelial cells …
EGFR/p38-MAPK/Sp1 signaling axis … In normal tissues, TGFβ signaling leaves the epithelial cells …
Repurposing of histone deacetylase inhibitors: A promising strategy to combat pulmonary fibrosis promoted by TGF-β signalling in COVID-19 survivors
… variety of cell types including epithelial cells, endothelial cells, and … to dysregulate EGFR
signalling by modulating EGFR ligands, … Moreover, effective inhibitions of COX-2 and Fas, and …
signalling by modulating EGFR ligands, … Moreover, effective inhibitions of COX-2 and Fas, and …