The liver sinusoid in chronic liver disease: NAFLD and NASH

WWJ Kwanten, SM Francque - Sinusoidal Cells in Liver Diseases, 2024 - Elsevier
… In conclusion, structural and functional alterations related to IHVR and sinusoidal liver blood
… importance of ET-1 signaling in early NAFLD with lowering the NAFLD-induced increase in …

[HTML][HTML] The molecular basis of portal hypertension

DC Rockey - Transactions of the American Clinical and …, 2017 - ncbi.nlm.nih.gov
… The liver cellular microcirculation in the sinusoid (including … of ET-1 in patients with cirrhosis
is the injured liver itself (40–… of the first post-translational modifications of eNOS identified. …

Labile heme impairs hepatic microcirculation and promotes hepatic injury

FA Englert, RA Seidel, K Galler, Z Gouveia… - Archives of biochemistry …, 2019 - Elsevier
… As the liversinusoidal microcirculation and hepatocellular integrity. We here provide
experimental evidence that heme increases portal pressure via a mechanism that involves hepatic

Interaction between Hydrogen Sulfide and Endothelin-1 in Hepatic Perfusion and Mitochondrial Dynamics in Endotoxemia

SA Pennington - 2018 - search.proquest.com
… of H2S and ET-1 is associated with sinusoidal constriction and … of H2S to hepatic
microcirculatory and mitochondrial … exerts its effects on the extra-sinusoidal and sinusoidal sites of …

[HTML][HTML] Portal hypertension in patients with nonalcoholic fatty liver disease: Current knowledge and challenges

A Madir, I Grgurevic, EA Tsochatzis… - World Journal of …, 2024 - ncbi.nlm.nih.gov
… and damage to liver microcirculation. The severity of PH tends to be underestimated by …
around the sinusoid. IHVR is also elevated by extrasinusoidal compression caused by swollen …

ET-1 stimulates superoxide production by eNOS following exposure of vascular endothelial cells to endotoxin

D Gopalakrishna, S Pennington, A Karaa, MG Clemens - Shock, 2016 - journals.lww.com
… Our work in the liver microcirculation has shown that … uncouples ET-1 binding to ET B receptors
on hepatic sinusoidal endothelial … altered basal NOS activity. LPS pretreatment impaired …

Maternal microvascular dysfunction during preeclamptic pregnancy

AE Stanhewicz, VR Nuckols, GL Pierce - Clinical Science, 2021 - portlandpress.com
microcirculatory resistance, sinusoidal obstruction and … in NO bioavailability within the
hepatic microcirculation. The … is sensitive to the vasoconstrictor activity of ET-1 [56–58] and …

[PDF][PDF] HEPATIC STELLATE CELLS IN LIVER SINUSOID FUNCTION

L Perea, J Vallverdú, AE Muñoz… - CHRONIC LIVER … - researchgate.net
… of the function of the sinusoid and highlight its cross-talk with liver sinusoidal endothelial
cells. HEPATIC STELLATE CELLS PHENOTYPE AND ORIGIN Hepatic stellate cells (HSCs) are …

Role of oxidative and nitrosative stress in hepatic fibrosis

TTV Thuy, H Hai, N Kawada - Liver pathophysiology, 2017 - Elsevier
Liver sinusoidal endothelial cells (LSECs) have a morphologic phenotype that is unique in
mammals, with the combination of … Altered oxidative metabolism of triglyceride at both the …

When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition

Á Gasparics, L Rosivall, IA Krizbai… - American Journal of …, 2016 - journals.physiology.org
… This review describes these alterations in endothelial … The sinusoid capillaries in the bone
marrow (43) or the … this interaction do tumor cells reach the extrasinusoidal space (75). On the …