… the benefits of early diagnosis and early treatment with … In 2008, we first reported NBS for
Pompe disease in Taiwan … , a group of possible later-onset Pompe disease (LOPD) patients (3). …

… of early detection and identification of serious conditions in … significantly to the feasibility of
NBS for Pompe disease, such as … NBS in Taiwan resulted in identification of 9 cases of classic …

… the feasibility of newborn screening for Pompe disease based … the importance of early
diagnosis for optimal treatment with … Taiwan is also screening most newborns for Pompe disease, …

… be initiated as early as possible before irreversible damage … early identification of patients
with IOPD allows for very early … newborns, accounting for almost 45% of newborns in Taiwan, …

… shown to benefit from early diagnosis and early treatment [2,3]. … Taiwanese population, a
second-tier test for Pompe disease … it is possible to decrease the chance of identifying newborns …

… Combining the results of the 2 Taiwanese-based newborn screening … early as possible
before irreversible damage occurs. Our results indicate that an effective newborn screening …

… A few patients in Taiwan were closely followed before and after … We demonstrated the
screening results [6], defined the … However, true multiplex newborn screening was made possible …

… Pompe disease as a viable disorder to add to newborn … was implemented in Taiwan as early
as 2005 [20]. Since then, several … the findings from the first year of population-based Pompe …

… in the newborn screening (NBS) programme in Taiwan for PD… administering ERT as soon
as feasible and employing short-… Thus, our rapid diagnosis criteria for IOPD newborns showed …

… Pompe disease, first piloted in 2005 by NTUH NBS center, demonstrates that enzyme screening
using DBS in a population is feasible. … of newborn screening center of National Taiwan …