[HTML][HTML] … emission tomography techniques to measure active inflammation, fibrosis and angiogenesis: potential for non-invasive imaging of hypertensive heart failure
V Balogh, MG MacAskill, PWF Hadoke… - … in Cardiovascular …, 2021 - frontiersin.org
… The variety of pathways and radiotracers included in this review indicates that PET radiotracers
explored for one type of pathology have the potential to become valuable tools in other …
explored for one type of pathology have the potential to become valuable tools in other …
Molecular imaging in drug discovery and development
JR Lindner, J Link - Circulation: Cardiovascular Imaging, 2018 - Am Heart Assoc
… events that occur at the endothelial-blood interface has been valuable for discovering that
abnormal … For ischemic heart disease and heart failure, molecular imaging of the recruitment of …
abnormal … For ischemic heart disease and heart failure, molecular imaging of the recruitment of …
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development
… More recently, investigation of novel molecular targets and … In this review, we summarize the
current knowledge on novel … malignancies and is being explored as a possible therapy for a …
current knowledge on novel … malignancies and is being explored as a possible therapy for a …
Utility of positron emission tomography for drug development for heart failure
L Papadimitriou, PM Smith-Jones, CMS Sarwar… - American heart …, 2016 - Elsevier
… of such a new medication in an early preclinical stage and help design successful clinical …
, we explore the potential implications of PET in the development of new heart failure therapies …
, we explore the potential implications of PET in the development of new heart failure therapies …
Using Omics to Identify Novel Therapeutic Targets in Heart Failure
C Lteif, Y Huang, LA Guerra… - Circulation: Genomic …, 2024 - Am Heart Assoc
… literature reporting omics data on heart failure that can inform the development of novel
treatments or innovative treatment strategies for this disease. This includes polygenic risk scores …
treatments or innovative treatment strategies for this disease. This includes polygenic risk scores …
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
… Novel experimental approaches targeting cardiac fibroblasts are promising potential therapies
for heart disease. … least partially, through effects on cardiac connective tissue. This Review …
for heart disease. … least partially, through effects on cardiac connective tissue. This Review …
[HTML][HTML] Beyond Natriuretic Peptides: Unveiling the Power of Emerging Biomarkers in Heart Failure
R Licordari, M Correale, S Bonanno, M Beltrami… - Biomolecules, 2024 - mdpi.com
… Clinically, elevated levels of GSTP1 have been associated with various aspects of heart
failure. Studies have explored its correlation with the severity of HF, indicating its potential as a …
failure. Studies have explored its correlation with the severity of HF, indicating its potential as a …
A multidimensional sight on cardiac failure: uncovered from structural to molecular level
V Urmaliya, G Franchelli - Heart failure reviews, 2017 - Springer
… , it seems to limit the understanding and treatment of heart failure. The purpose of this review
is to characterize heart failure from a new multidimensional perspective that focuses on the …
is to characterize heart failure from a new multidimensional perspective that focuses on the …
New approaches to target inflammation in heart failure: harnessing insights from studies of immune cell diversity
AJ Rhee, KJ Lavine - Annual review of physiology, 2020 - annualreviews.org
… and mouse models of ischemia, hypertensive heart disease, and aortic stenosis. Specific …
these populations on cardiac remodeling. Finally, we discuss strategies to target inflammatory …
these populations on cardiac remodeling. Finally, we discuss strategies to target inflammatory …
Cellular and molecular pathobiology of heart failure with preserved ejection fraction
… and cardiac disease as occurs in the majority of patients with HFpEF, are beginning to
reveal novel molecular mechanisms and therapeutic targets. … In addition to exploring novel …
reveal novel molecular mechanisms and therapeutic targets. … In addition to exploring novel …