… the cell surface where phospholipases actively modify the cell membrane, the cytoplasm …
the ER with neutral lipid hydrolases, and the entire endosomal pathway from early endosome to …

… for the analysis of CD1d-bound lipids in mammalian cells … is facilitated by lipid transfer and
editing proteins such as the … as colocalization with markers of early endosomes (EEA1) and …

… Therefore, CD1 molecules require lipid transfer proteins for lipid loading and editing. CD1d
is loaded with lipids in late endocytic compartments, and lipid transfer proteins of the saposin …

… of CD1d in endosomal compartments. Thus, it seems possible to modify the interactions
with lipid antigens and with other proteins by just protonating a few specific residues. However, …

… peptide antigens are chemically processed, many lipids are … However, each type of CD1
protein differentially edits the self… ) lipid anchors strictly require low pH and other endosomal …

… CD1a molecules mainly localize in early endosomes and possess the smallest groove, …
and lipid-transfer proteins that process lipid antigens and assist the loading of lipids onto CD1 …

… lipids are facilitated by LTPs in late endosomes and lysosomes. Within the small group of …
-loading onto CD1 molecules, tapasin and HLA-DM assist in peptide editing and loading onto …

… each CD1 protein recycles through the endosomal network correlates with the degree to
which an acidic pH is needed for lipid antigen capture. CD1c and CD1d capture antigens less …

… views that emphasize antigen-driven T cell activation, here we used an unbiased cell screen
to discover endogenous lipids that are selectively captured by CD1a proteins in cells and …

… that interact with adaptor proteins [71,72,73,74]. While CD1a travels to the early endosome,
CD1b and CD1c travel to the late endosome and the intermediate endosome, respectively. …