[HTML][HTML] N-Acetyl-L-Cysteine inhibits the development of glucose intolerance and hepatic steatosis in diabetes-prone mice

A Falach-Malik, H Rozenfeld, M Chetboun… - American journal of …, 2016 - ncbi.nlm.nih.gov
… have shown a beneficial effect of chronic treatment with NAC … of total calories derived from
fatty acids, 18.4% from proteins … either enhanced insulin sensitivity or elevated insulin secretion…

The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies

PV Dludla, SE Mazibuko-Mbeje, TM Nyambuya… - Pharmacological …, 2019 - Elsevier
… a persistent link has been acknowledged between increased … reducing free fatty acid-induced
perilipin expression … inhibitory effect of lipid accumulation, amelioration of insulin resistance

N-Acetyl-l-Cysteine treatment efficiently prevented pre-diabetes and inflamed-dysmetabolic liver development in hypothalamic obese rats

HG Villagarcía, MC Castro, LG Arbelaez, G Schinella… - Life sciences, 2018 - Elsevier
Chronic NAC treatment in MSG rats efficiently decreased the high circulating levels of … in
a model of unhealthy diet intake that inflammation, insulin resistance (IR) and OS constitute a …

[HTML][HTML] Effect of N-acetylcysteine on antioxidant defense, oxidative modification, and salivary gland function in a rat model of insulin resistance

P Żukowski, M Maciejczyk, J Matczuk… - … Medicine and Cellular …, 2018 - hindawi.com
… determine whether a chronic treatment of high-fat fed rats with … In the case of a high-fat diet,
the excess fatty acid supply in the … by N-acetyl-L-cysteine and ramipril in a rat model of insulin

N-acetylcysteine protects mice from high fat diet-induced metabolic disorders

Y Ma, M Gao, D Liu - Pharmaceutical research, 2016 - Springer
… , fatty liver, and insulin resistance. Mechanistically, the beneficial … also increased mRNA
levels of genes involved in fatty acid … Consequently, chronic inflammation blunts insulin action in …

[HTML][HTML] N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

M Schuurman, M Wallace, G Sahi, M Barillaro… - Frontiers in …, 2022 - frontiersin.org
insulin resistance, where peripheral tissue insulin receptors become insensitive and require
increased insulin … changes, prolonged high fat diet (HFD)-induced compensation affects the …

[HTML][HTML] Maternal N-acetyl cysteine intake improved glucose tolerance in obese mice offspring

M Michlin, L Argaev-Frenkel… - International Journal of …, 2020 - mdpi.com
… was to investigate the effects of N-acetyl-l-cysteine (NAC) given … developed due to this
chronic hyperinsulinemia, as found in … with NAC not only prevented insulin resistance, but also …

Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine …

WA Keshk, MA Ibrahim, SM Shalaby, ZA Zalat… - Archives of biochemistry …, 2020 - Elsevier
Increased long term intake of HFD impairs whole body … may be due to increased level of
the circulating free fatty acids, as a … as NF-ϰB, inflammation and insulin resistance. Peripheral …

Effect of N-acetyl-L-cysteine prevention or intervention on diet induced beta cell compensation and dysfunction

M Wallace - 2019 - search.proquest.com
… Short- and long-term antioxidant treatment of T2DM with … stress levels in peripheral tissue
and improve insulin resistance … ) accumulation caused by increased intake of free fatty acids (…

Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

AM Garcia-Serrano, JPP Vieira… - Nutritional …, 2023 - Taylor & Francis
… after glucose intolerance and insulin resistance were installed [… syndrome, without the
chronic insulin receptor stimulation in … have beneficial effects on HFD-induced alterations of …