Effect of asbestos exposure on the frequency of EGFR mutations and ALK/ROS1 rearrangements in patients with lung adenocarcinoma: a multicentric study
Journal of Occupational and Environmental Medicine, 2021•journals.lww.com
Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-
driver mutations. Methods: Between January 2014 and September 2018, epidermal growth
factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros
oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics,
asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung
adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and …
driver mutations. Methods: Between January 2014 and September 2018, epidermal growth
factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros
oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics,
asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung
adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and …
Abstract
Objective:
The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations.
Methods:
Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded.
Results:
The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure.
Conclusions:
The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
Lippincott Williams & Wilkins