Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of …

AM Mahmoud, HM Mohammed, SM Khadrawy… - Chemico-Biological …, 2017 - Elsevier
… Hepatocarcinogenesis was initiated with DEN and promoted … of DEN/CCl 4 -induced rats,
an effect that was significantly … hepatic cell proliferation and hence inhibited the initiation of …

[HTML][HTML] Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on …

W Wei, R Li, Q Liu, VD Seshadri… - Arabian Journal of …, 2021 - Elsevier
… anticancer action against the DMH-provoked CRC in rats. In … Effect of SAP-Ally-NCs on the
TBARS level in the liver and … cells, initiating with hyperplasia and gradually developing into …

[HTML][HTML] Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat …

S Bettini, E Boutet-Robinet, C Cartier, C Coméra… - Scientific reports, 2017 - nature.com
… fate of TiO 2 along the gut-liver axis in rats that were orally given … the promotion of preneoplastic
lesions (ie, ACF) in vivo in rats … the effect of food-grade TiO 2 particles on the initiation of …

[HTML][HTML] Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis

I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
tumor initiating cell (TIC). The main aim of this review is to shed light about the pleiotropic
actions of TGF-β that explain its effects on the different liver … Fibrosis-induced model in rats by …

[HTML][HTML] Resveratrol: A double-edged sword in health benefits

B Salehi, AP Mishra, M Nigam, B Sener, M Kilic… - Biomedicines, 2018 - mdpi.com
stages (eg, initiation, promotion and progression). Even more, other bioactive effects, namely
… on lipoperoxidation levels (in heart, liver and kidney of male rats synchronized with a 12-h …

The role of natural polyphenols in cell signaling and cytoprotection against cancer development

H Lewandowska, M Kalinowska… - … nutritional biochemistry, 2016 - Elsevier
… main stages have been described: initiation, promotion and progression. … hepatic injury in
rats, and this effect was at least in part related to NRF2-mediated increase of HO-1 expression […

Dietary fat and mammary cancer

LA Cohen - Diet, Nutrition and cancer: A critical evaluation, 2018 - taylorfrancis.com
effect of dietary fat was to enhance (or promote) the development of tumors in already
initiated … fat on incidence of mammary tumors induced in female Sprague-Dawley rats by 7,12-…

[HTML][HTML] Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action

S Bhattacharya, A Perris, JJ Jawed, M Hoda - … Research-Modern Chinese …, 2023 - Elsevier
Tumor promotion is primarily associated with the alteration of … trigger the initiation stage of
disease development. Resveratrol … hepatic injury in rats. Resveratrol demonstrates preventive …

[HTML][HTML] Insights into the role and interdependence of oxidative stress and inflammation in liver diseases

S Li, M Hong, HY Tan, N Wang, Y Feng - Oxidative medicine and …, 2016 - hindawi.com
… in the liver are crucial in the initiation and development of hepatic … may promote hepatic
inflammation through upregulation of … in experimental rat liver fibrosis: protective effect of taurine,” …

[HTML][HTML] Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats

F Khan, TJ Khan, G Kalamegam, PN Pushparaj… - … and alternative medicine, 2017 - Springer
… In vivo hepatic cancer model development is done using … in the initiation, maintenance and
progression of tumors [19]. … IL-4, which is implicated in tumor promoting activities however, …