Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of …
AM Mahmoud, HM Mohammed, SM Khadrawy… - Chemico-Biological …, 2017 - Elsevier
… Hepatocarcinogenesis was initiated with DEN and promoted … of DEN/CCl 4 -induced rats,
an effect that was significantly … hepatic cell proliferation and hence inhibited the initiation of …
an effect that was significantly … hepatic cell proliferation and hence inhibited the initiation of …
[HTML][HTML] Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on …
W Wei, R Li, Q Liu, VD Seshadri… - Arabian Journal of …, 2021 - Elsevier
… anticancer action against the DMH-provoked CRC in rats. In … Effect of SAP-Ally-NCs on the
TBARS level in the liver and … cells, initiating with hyperplasia and gradually developing into …
TBARS level in the liver and … cells, initiating with hyperplasia and gradually developing into …
[HTML][HTML] Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat …
S Bettini, E Boutet-Robinet, C Cartier, C Coméra… - Scientific reports, 2017 - nature.com
… fate of TiO 2 along the gut-liver axis in rats that were orally given … the promotion of preneoplastic
lesions (ie, ACF) in vivo in rats … the effect of food-grade TiO 2 particles on the initiation of …
lesions (ie, ACF) in vivo in rats … the effect of food-grade TiO 2 particles on the initiation of …
[HTML][HTML] Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis
I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
… tumor initiating cell (TIC). The main aim of this review is to shed light about the pleiotropic
actions of TGF-β that explain its effects on the different liver … Fibrosis-induced model in rats by …
actions of TGF-β that explain its effects on the different liver … Fibrosis-induced model in rats by …
[HTML][HTML] Resveratrol: A double-edged sword in health benefits
… stages (eg, initiation, promotion and progression). Even more, other bioactive effects, namely
… on lipoperoxidation levels (in heart, liver and kidney of male rats synchronized with a 12-h …
… on lipoperoxidation levels (in heart, liver and kidney of male rats synchronized with a 12-h …
The role of natural polyphenols in cell signaling and cytoprotection against cancer development
H Lewandowska, M Kalinowska… - … nutritional biochemistry, 2016 - Elsevier
… main stages have been described: initiation, promotion and progression. … hepatic injury in
rats, and this effect was at least in part related to NRF2-mediated increase of HO-1 expression […
rats, and this effect was at least in part related to NRF2-mediated increase of HO-1 expression […
Dietary fat and mammary cancer
LA Cohen - Diet, Nutrition and cancer: A critical evaluation, 2018 - taylorfrancis.com
… effect of dietary fat was to enhance (or promote) the development of tumors in already
initiated … fat on incidence of mammary tumors induced in female Sprague-Dawley rats by 7,12-…
initiated … fat on incidence of mammary tumors induced in female Sprague-Dawley rats by 7,12-…
[HTML][HTML] Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
… Tumor promotion is primarily associated with the alteration of … trigger the initiation stage of
disease development. Resveratrol … hepatic injury in rats. Resveratrol demonstrates preventive …
disease development. Resveratrol … hepatic injury in rats. Resveratrol demonstrates preventive …
[HTML][HTML] Insights into the role and interdependence of oxidative stress and inflammation in liver diseases
… in the liver are crucial in the initiation and development of hepatic … may promote hepatic
inflammation through upregulation of … in experimental rat liver fibrosis: protective effect of taurine,” …
inflammation through upregulation of … in experimental rat liver fibrosis: protective effect of taurine,” …
[HTML][HTML] Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats
… In vivo hepatic cancer model development is done using … in the initiation, maintenance and
progression of tumors [19]. … IL-4, which is implicated in tumor promoting activities however, …
progression of tumors [19]. … IL-4, which is implicated in tumor promoting activities however, …