The pharmacology of the genus Sophora (Fabaceae): An updated review

SH Aly, AM Elissawy, OA Eldahshan, MA Elshanawany… - Phytomedicine, 2019 - Elsevier
effects such as neural inhibition, tremors, convulsions and respiratory paralysis. Anagyrine
is well known for its teratogenic effect in cattle … flavescens. Likewise matrine, it also exhibited …

Effects of plant extracts and derivatives on cardiac K+, Nav, and Cav channels: a review

I Seck, SF Ndoye, MVK Kapchoup… - Natural Product …, 2024 - Taylor & Francis
… with cardiac contractions such as myocardial contractility by … , neurotransmitters, and
hormone secretion. Cation channel … the traditional Chinese herb Sophora flavescens, inhibits …

Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

J He, S Li, Y Ding, Y Tong, X Li - Cardiovascular Therapeutics, 2022 - Wiley Online Library
… improved myocardial contractility and cardiac function and prevented heart failure in rats with
… In addition, tanshinone IIA inhibited collagen secretion induced by AngII and the synthesis …

Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity

L Lin, Y Chen, Q Li, G Xu, K Ding, L Ren, W Shi… - Journal of …, 2022 - Elsevier
… inflammasomes, we tested the effects of IXN on four … 1β secretion in response to ATP or
nigericin in LPS-primed BMDMs, but had no effect on caspase-1 activation and IL-1β secretion of …

[PDF][PDF] Vasodilatory effects of aloperine in rat aorta and its possible mechanisms

C Yang, Y Yu, F Wu, Y Wu, J Feng, L Yan, L Han, J Ren… - Chin. J. Physiol, 2018 - cps.org.tw
… of vasoreactivity plays a pivotal role in treatment in cardiovascular disease (10, 34, 41, 44…
functions (3, 25, 31). Endothelial cells regulate vascular tone by secreting a series of contractile

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

S Wei, J Xiao, F Ju, J Liu, Z Hu - Frontiers in Pharmacology, 2024 - frontiersin.org
… as Sophora alopecuroides L., Sophora flavescens Ait., and … its antiarrhythmic function is
the result of its combined effect … and protective effects of sophocarpine on other types of heart

Matrine exerts pharmacological effects through multiple signaling pathways: a comprehensive review

Y Lin, F He, L Wu, Y Xu, Q Du - Drug Design, Development and …, 2022 - Taylor & Francis
Sophora flavescens Ait as well as Sophora alopecuroides Linn, … Contractile-synthetic
phenotypic conversion of VSMCs … plaque through abnormal synthesis, secretion, and deposition of …

Current state and future perspective of cardiovascular medicines derived from natural products

C Zhao, S Li, J Zhang, Y Huang, L Zhang… - Pharmacology & …, 2020 - Elsevier
cardiovascular medicine has been extensively documented, and many have been used for
centuries. Cardiovascular … 50% of newly developed cardiovascular drugs were based on NPs…

[HTML][HTML] Research advances on matrine

XY Sun, LY Jia, Z Rong, X Zhou, LQ Cao, AH Li… - Frontiers in …, 2022 - frontiersin.org
… herbs such as Sophora flavescens, Sophora alopecuroides, … (human coronary artery smooth
muscle cells) from contractile … NF-κB signaling pathway is closely related to the secretion of …

Research Advancements in Pharmacological Activities and Mechanisms of Matrine

X Chen, P Liu, Y Mao, G Wang - Pharmacognosy Magazine, 2024 - journals.sagepub.com
… medicine Sophora flavescens extract, along with fewer side effects … aureus alpha-hemolysin
secretion and downregulating the … contractility and improved cardiac mechanical functions. …