… : The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation

X Jin, S Ren, E Macarak, J Rosenbloom - Matrix Biology, 2016 - Elsevier
… While TGF-β is secreted into the ECM as a large latent … the Ras–MAPK (mitogen-activated
protein kinase) pathway [… However, the use of steroids, which can have manifold effects, would …

TGF-β, IL-1β, IL-6 levels and TGF-β/Smad pathway reactivity regulate the link between allergic diseases, cancer risk, and metabolic dysregulations

Z Elkoshi - Frontiers in Immunology, 2024 - frontiersin.org
… (who did not use corticosteroids) compared to 14 healthy … Th17 cells release IL-17, IL-21,
and IL-22, which are dominant … to inhibit TGF-β signaling by reducing the phosphorylation of …

Interleukin-6 and type-I collagen production by systemic sclerosis fibroblasts are differentially regulated by interleukin-17A in the presence of transforming growth …

AM Dufour, M Alvarez, B Russo… - Frontiers in …, 2018 - frontiersin.org
TGF-β is secreted as a latent protein, which needs to be … under immunosuppressive agents
or glucocorticoids. This study … presence of TGF-β and IL-17A, the phosphorylation of SMAD2 …

The role of transforming growth factor β in T helper 17 differentiation

S Zhang - Immunology, 2018 - Wiley Online Library
… (mTOR), mitogen-activated protein kinase (MAPK) pathways (… For example, serum
glucocorticoid kinase 1 (SGK1) can be … diet through phosphorylation of p38 MAPK, which …

IL‐6 Signaling Link between Inflammatory Tumor Microenvironment and Prostatic Tumorigenesis

CV Ene, I Nicolae, B Geavlete… - Analytical Cellular …, 2022 - Wiley Online Library
IL-6 is mostly secreted by macrophages and also by T and B … by the active complex IL-6/IL-6R.
The involvement of … activity at posttranslational levels (phosphorylation, ubiquitination, de-…

New insights into the novel anti-inflammatory mode of action of glucocorticoids

DK Ingawale, SK Mandlik - Immunopharmacology and …, 2020 - Taylor & Francis
… described effects of Anx-1 may be attributed to release of IL-… that dephosphorylates
Mitogen-activated protein kinases (MAPKs… done by phosphorylation and inactivation of TTP by …

Epithelial growth factor receptor tyrosine kinase inhibitors alleviate house dust mite allergen Der p2‐induced IL‐6 and IL‐8

HH Pan, YP Hsiao, PJ Chen, YT Kang… - Environmental …, 2019 - Wiley Online Library
… by inhaled corticosteroids is associated with elevated IL-6, … /ERK (MAPK kinase/extracellular
signal-regulated kinase), … by the phosphorylation of α subunit via the upstream kinases

Effect of interleukin-6,-17,-21,-22, and-23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis

I Woś, J Tabarkiewicz - Immunologic Research, 2021 - Springer
… of IL-1, IL-6, IL-23, and transforming growth factor β (TGFβ) … the mitogen-activated protein
kinase (MAPK) pathways [21]. … of noted importance IL-6 transmits signals by phosphorylation of …

The MAP Kinase/MAP Kinase Phosphatase-1 Pathway in the Anti-Inflammatory Effects of β2-Agonists and Dexamethasone

T Keränen - 2019 - trepo.tuni.fi
… production and release of inflammatory … glucocorticoid dexamethasone inhibits the
phosphorylation of p38 and JNK in bone marrow-derived macrophages from WT mice, while the …

Pro-inflammatory cytokines: cellular and molecular drug targets for glucocorticoid-induced-osteoporosis via osteocyte

T Wang, X Yu, C He - Current drug targets, 2019 - ingentaconnect.com
… by increasing the secretion of a glucocorticoid-releasing … NF-κB) and mitogen-activated
protein kinase (MAPK) are two … stimulate more rapid and marked phosphorylation of ERK1/2 …