Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases

RK Singh, AK Najmi, SG Dastidar - Pharmacological Reports, 2017 - Springer
… p38 phosphorylates MK2 kinase leading to inhibition of TTP protein, and consequent activation
and release of inflammatory cytokines such as TNF-a, IL-1b, IL-… and corticosteroids in the …

Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma

R Halwani, A Sultana, A Vazquez-Tello… - Journal of …, 2017 - Taylor & Francis
… Patients were receiving high-dose inhaled corticosteroids or … also inhibited IL-21 + IL-23-induced
STAT3 phosphorylation … triggers their production and release of proinflammatory and …

[HTML][HTML] Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression

N Lu, CJ Malemud - International journal of molecular sciences, 2019 - mdpi.com
phosphorylated by members of the upstream MAP kinase … exchange on RAS, forcing
the release of the bound nucleotide (… molecular weight hyaluronan inhibited IL-6-IL-6R-induced …

[HTML][HTML] Influence of the TGF-β superfamily on osteoclasts/osteoblasts balance in physiological and pathological bone conditions

J Jann, S Gascon, S Roux, N Faucheux - International journal of …, 2020 - mdpi.com
MAPK (Mitogen-activated protein kinase) pathways that control reciprocal expression of Runx2
and PPARγ and their phosphorylation … TNF-α, IL-1β, IL-6 IL-7, and IL-15 can also induce …

IL-6 and its role in IgA nephropathy development

Y Groza, J Jemelkova, LR Kafkova, P Maly… - Cytokine & Growth Factor …, 2022 - Elsevier
… gp130 or another already formed complex IL-6/IL-6Rα/gp130 via … , which in turn phosphorylates
and activates MAPK kinase. … why the steroids therapy did not have the impact on the …

[HTML][HTML] Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

T Southworth, J Plumb, V Gupta, J Pearson, I Ramis… - Respiratory …, 2016 - Springer
… -inflammatory effects of PI3Kδ and JAK inhibition on release of T… of STAT protein
phosphorylation interferes with the ability to … effects when these drugs are combined with …

[HTML][HTML] The physiological and pathophysiological role of IL-6/STAT3-mediated signal transduction and STAT3 binding partners in therapeutic applications

T Matsuda - Biological and Pharmaceutical Bulletin, 2023 - jstage.jst.go.jp
… Here, I describe the IL-6/IL-6R system and its downstream … Ras-Raf-mitogen-activated protein
kinase (MAPK) pathway and … Ser727 phosphorylation in the early but not late phase of IL-6…

Differential regulation of toll‐like receptor‐mediated cytokine production by unfolded protein response

S Kim, Y Joe, YJ Surh, HT Chung - Oxidative medicine and …, 2018 - Wiley Online Library
… of proteins, biosynthesis of steroids, cholesterol and other … kinase activity of IRE1α directly
triggers IκB phosphorylation … generation are responsible for IL-1β and IL-18 secretions [38]…

[HTML][HTML] Regulation of osteoblast differentiation by cytokine networks

DS Amarasekara, S Kim, J Rho - International journal of molecular …, 2021 - mdpi.com
… differentiate into mature OBs that secrete collagen type 1 alpha 1 … Phosphorylated β-catenin
is ubiquitinated by β-TrCP ubiquitin … through the mitogen-activated protein kinase (MAPK) …

[HTML][HTML] Skeletal muscle wasting and renewal: a pivotal role of myokine IL-6

JE Belizário, CC Fontes-Oliveira, JP Borges… - Springerplus, 2016 - Springer
… distinct effects may be explained by a crosstalk of the IL-6/IL-… regulated kinase)/MAPK (mitogen-activated
protein kinase) … reduction in phosphorylation of ribosomal protein kinase S6K1 …