The impact of steroids on the injured podocytes in nephrotic syndrome

SMH Khatibi, M Ardalan, S Abediazar… - The Journal of Steroid …, 2020 - Elsevier
… VEGF secretion and expression are also downregulated by … through the mitogenactivated
protein kinase (MAPK) signaling … ERK phosphorylation, Dex applies a pro-apoptotic effect that …

Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice

Y Luo, H Chen, R Huang, Q Wu, Y Li, Y He - Pulmonary pharmacology & …, 2021 - Elsevier
… Furthermore, the use of glucocorticoids also has its own set … phosphorylation cascade: the
active MAPK kinases (ie MKK3, … from IL-6, other cytokines, for instance IL-4 and IL-13 secreted

Berberine suppresses IL-33-induced inflammatory responses in mast cells by inactivating NF-κB and p38 signaling

W Li, N Yin, W Tao, Q Wang, H Fan, Z Wang - International …, 2019 - Elsevier
… the phosphorylation of mitogen-activated protein kinase (MAPK) … effect and explored the
underlying mechanisms of BBR on IL-… reduced IL-33-induced cytokine secretion, inhibited IL-33-…

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
… The activation of kinase causes the phosphorylation of … MAPK like MAPK kinase kinases
(MAPKKK) and MAPK … Macrophages liberate Il-23 to act on TH17 cells which release IL-17 and …

AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung …

JMG Yap, T Ueda, Y Kanemitsu, N Takeda… - Respiratory …, 2021 - Springer
… We examined the effect of AITC on Smad2/3 phosphorylationMitogen-activated protein
kinase (MAPK) signaling pathways … channel was involved in excessive IL-8 release in TNF-α-…

Interleukin (IL)-7 signaling in the tumor microenvironment

I Bednarz-Misa, MA Bromke… - … of Interleukins–Part B, 2021 - Springer
… Sequestration of secreted IL-7 is likely to contribute to the relatively low concentrations …
steroids or histone deacetylase (HDAC) inhibitors [150]. In addition, direct JAK3 phosphorylation

Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways

S Malik, K Suchal, SI Khan, J Bhatia… - American Journal …, 2017 - journals.physiology.org
… and secretion is increased in the diabetic kidney (14, 18). … on MAPK activation by determining
the phosphorylation of … stress also activates mitogen-activated protein kinases (MAPKs…

TGF-β in T cell biology: implications for cancer immunotherapy

A Dahmani, JS Delisle - Cancers, 2018 - mdpi.com
… such as phosphorylation and activation of the Tec kinase Itk, … of the mitogen-activated protein
kinase ERK Tec kinase, … anticancer effects following agonistic stimulation of glucocorticoid-…

Interleukin (IL-6) immunotherapy

T Tanaka, M Narazaki… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
IL-6 in combination with transforming growth factor β (TGF-β) … other and to lead to
phosphorylation in the cytoplasmic tyrosine … The mean survival time difference to stop …

Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling

S Liu, C Zhang, B Wang, H Zhang, G Qin, C Li… - Cancer Immunology …, 2021 - Springer
effects of TGF-β on GSCs, we performed a multiple-cytokine assay to investigate cytokine
secretion … Similarly, we observed that the phosphorylation of STAT3 (p-STAT3) was activated in …