The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

J Vevera, K Valeš, Z Fišar, J Hroudová, N Singh… - Physiology & …, 2016 - Elsevier
… ie the hippocampus, striatum and frontal cortex. Also, a link between impairment of serotonin
… of sertraline, also a selective serotonin reuptake inhibitor, but did not change the effect of …

[HTML][HTML] Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate

GA Eger, VV Ferreira, CR Batista, H Bonde… - Anais da Academia …, 2016 - SciELO Brasil
Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex
and striatum among SD rats. … in which simvastatin upregulated NMDAR in the rat brain, and …

[HTML][HTML] The effect of atorvastatin on obsessive-compulsive symptoms of refractory obsessive-compulsive disorder (add-on therapy)

S Akouchekian, V Omranifard, P Moshfegh… - Advanced Biomedical …, 2018 - journals.lww.com
… guides, selective serotonin reuptake inhibitors (SSRIs) and … prefrontal cortex with potential
mechanisms of endothelial nitric oxide synthase. The results of this study suggest that statins

Effects of statins on dopamine loss and prognosis in Parkinson's disease

SH Jeong, HS Lee, SJ Chung, HS Yoo, JH Jung… - Brain, 2021 - academic.oup.com
… total cholesterol level mediated the associations between statin use … to be associated with
cholesterol level, were entered as … statin increases striatal dopamine content without affecting …

Update on statin treatment in patients with neuropsychiatric disorders

R Avan, A Sahebnasagh, J Hashemi, M Monajati… - Life, 2021 - mdpi.com
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… association between
anxiety and non-adherence to statinsdopamine concentrations in the prefrontal cortex [114,115]. …

Statins and the brain: more than lipid lowering agents?

A Fracassi, M Marangoni, P Rosso… - Current …, 2019 - ingentaconnect.com
… indicates that the relationship between statins and PD is not … regions and by the release
of striatal dopamine [255]. Cruz … in the hippocampus and prefrontal cortex, two brain regions …

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… , amongst its two groups, lipophilic statins have a higher ability … of simvastatin for 4 weeks in
SpragueDawley rats restored … significantly increased dopamine content in the striatum [168]…

Rosuvastatin improves olanzapine's effects on behavioral impairment and hippocampal, hepatic and metabolic damages in isolated reared male rats

A Mohammed, WM El-Bakly, A Ali… - Behavioural Brain …, 2020 - Elsevier
… such as serotonin (5-HT) and dopamine (DA), and dysfunction of these … In addition, statins
showed neuroprotective effects in … changes among all of the groups where: A and B, SR rats, …

Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder

K Liu, X Zhao, X Lu, X Zhu, H Chen, M Wang… - Psychological …, 2019 - cambridge.org
level in MDD patients. In another word, the extent of FC decrease between striatum and
prefrontal cortices after SSRI treatment was less significant in MDD individuals with a high level

Effects of simvastatin beyond dyslipidemia: Exploring its antinociceptive action in an animal model of complex regional pain syndrome-type I

G Vieira, J Cavalli, ECD Gonçalves… - Frontiers in …, 2017 - frontiersin.org
… There are some evidences exploring the relation between simvastatin and its central
effects, such as: (i) altering dopamine D1 and D2 receptors, Wang et al. (2005, 2006); (ii) …