[HTML][HTML] Repeated intrastriatal botulinum neurotoxin-A injection in hemiparkinsonian rats increased the beneficial effect on rotational behavior

A Hawlitschka, C Holzmann, A Wree, V Antipova - Toxins, 2018 - mdpi.com
… Our results concerning the more profound effect of the second intrastriatal BoNT-A
injection, were in line with the prolongation of the therapeutic intervals observed following …

[HTML][HTML] Unilateral botulinum neurotoxin-A injection into the striatum of C57BL/6 mice leads to a different motor behavior compared with rats

V Antipova, A Wree, C Holzmann, T Mann… - Toxins, 2018 - mdpi.com
… : We investigated the effect of intrastriatal BoNT-A application on motor behavior in naïve …
of the BoNT-A effect in mice and rats, multi-receptor fingerprints of Wistar rats and C57Bl/6 mice …

Intrastriatal injection of botulinum neurotoxin-A is not cytotoxic in rat brain–a histological and stereological analysis

J Mehlan, H Brosig, O Schmitt, E Mix, A Wree… - Brain research, 2016 - Elsevier
… Furthermore the intrastriatal application of BoNT-A leads to axonal swellings which we
named botulinum toxin-… Behavioral and structural effects of unilateral intrastriatal injections of …

[HTML][HTML] Antidepressant-like properties of intrastriatal botulinum neurotoxin-a injection in a unilateral 6-ohda rat model of parkinson's disease

V Antipova, C Holzmann, A Hawlitschka, M Witt… - Toxins, 2021 - mdpi.com
… Therefore, in the present study, we aimed to examine a possible therapeutic effect of
intrastriatal injections of BoNT-A on depression-like behavior in the hemi-PD rat model induced by …

[HTML][HTML] Experimental intrastriatal applications of botulinum neurotoxin-A: A review

A Hawlitschka, A Wree - International Journal of Molecular Sciences, 2018 - mdpi.com
intrastriatal injection (Figure 2A) of 1–2 ng BoNT-A into the right CPu of Wistar rats led to an
apomorphine-induced turning behavior … This effect was observed from two weeks up to three …

[HTML][HTML] Botulinum neurotoxin a injected ipsilaterally or contralaterally into the striatum in the rat 6-OHDA model of unilateral Parkinson's disease differently affects …

VA Antipova, C Holzmann, O Schmitt… - Frontiers in Behavioral …, 2017 - frontiersin.org
rats inhibit apomorphine-induced rotation behavior … the behavioral testing of ipsilateral
botulinum neurotoxin A (BoNT-A)-injection and additionally investigated the impact of intrastriatal

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D2R binding and reduces striatal D1R binding in male hemiparkinsonian rats

F Wedekind, A Oskamp, M Lang… - Journal of …, 2018 - Wiley Online Library
intrastriatal BoNT-A administration normalizes D 2 receptor binding in hemiparkinsonian rats,
in correlation to behavioral … Moreover, we assume that the long-lasting impact on behavior

Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice

A Hawlitschka, C Holzmann, S Witt, J Spiewok… - Brain Research, 2017 - Elsevier
… of BoNT-A as a functional blocker of synaptic transmission is correlated to the number of
BiVs our data nicely fit with our results in behavioral changes of BoNT-A treated hemi-PD rats. …

Dopamine, noradrenaline and serotonin receptor densities in the striatum of hemiparkinsonian rats following botulinum neurotoxin-A injection

T Mann, K Zilles, H Dikow, A Hellfritsch, M Cremer… - Neuroscience, 2018 - Elsevier
effect of BoNT-A on the impaired motor behavior of hemi-PD … intrastriatal Botulinum
neurotoxin-A (BoNT-A) administration as a highly potent new therapeutic option in hemi-PD rats (…

Repeated intrastriatal application of botulinum neurotoxin-A did not influence choline acetyltransferase-immunoreactive interneurons in hemiparkinsonian rat brain–A …

A Hawlitschka, C Berg, O Schmitt, C Holzmann, A Wree… - Brain Research, 2020 - Elsevier
… when injected intrastriatally. In hemiparkinsonian (hemi-PD) rats, a unilateral intrastriatal
injection … -induced rotation behavior for at least 3 months, the effect fading thereafter. A second …