… large C-terminal moiety is not directly involved in nuclease activity. … transcription elongation
that are compatible with either increased RNA pol II processivity or decreased elongation rate…

… II stranded on the template and easily terminated by XRN2, which degrades the
polymerase-associated product of PAS cleavage. Abbreviations: CPA, cleavage and …

… degradation of 3′ flanking region RNA and transcriptional termination. This defect is …
elongating transcript sequencing (mNET-seq). An Xrn2 effect on termination requires prior RNA …

… Xrn2 torpedo chases the elongating polymerase while Xrn2 … effects of Rat1 are necessary
for efficient pol II release in yeast. … The transcription elongation complex has been of interest to …

… We found significant effects of Xrn1 perturbation on RNA pol … and the activity of the Rat1
(Xrn2) exonuclease (see 12, 13 for … C-terminal moiety is not directly involved in nuclease activity. …

… of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth ride. Transcript
elongation … , nucleosomes, RNA secondary structures and the underlying DNA sequence. …

… in some cases RNA polymerase II (RNAPII) transcription regulation … following XRN2 depletion
might underlie the effects we have … R loops formed during transcriptional elongation and/or …

… transcript by Xrn2 up to the arrested Pol II (57). In effect, these experiments argue that the act
of removing RNA up to or into the … Early transcription elongation is restricted by two negative …

… Transcription of the eukaryotic genome is carried out by the nuclear RNA polymerase I (Pol
I), Pol II and Pol III. … Factor b) mediated counteraction of the negative effects of DSIF (DRB …

… are subject to degradation by nucleases such as 5′-3′ exoribonuclease 2 (XRN2), which
… II pausing following a long period of selection, which could include many indirect effects of …