… However, the efficacy of agomelatine on inflammatory periodontal disease has not been
studied so far. In the present work, we tried to assess the influences and potential mechanisms …

… , agomelatine could represent a novel antidepressant with higher therapeutic efficacy. Studies
… We investigated and compare the binding properties of GW117 to agomelatine at ES-620 (…

… agomelatine, with its unique pharmacological properties as … receptor agonist and 5-HT 2B
/5-HT 2C serotonin receptor … the antagonistic action of agomelatine at 5-HT 2C receptors per se…

… receptors and the serotoninergic 5-HT2c receptor giving rise to the Melatonin Agonist and
Selective Serotonin Antagonist (… finding and efficacy study: 25 mg of agomelatine once daily at …

… 2 melatonergic receptors of SCN and antagonize 5-HT 2c receptors in … Its 5-HT2c antagonism
also enhances frontocortical … In addition to its therapeutic efficacy, agomelatine does not …

… A brief review of the efficacy of agomelatine as an antidepressant is … of the MT1/MT2
antagonist, S22153. Administration of … agonist and 5HT2C antagonist properties of agomelatine to …

… In conclusion, agomelatine expresses its therapeutic efficacy in GAD principally via its
antagonist properties at 5-HT 2C receptors with MT 1 /MT 2 agonism providing complementary …

… The antagonism of agomelatine on 5-HT 2C receptors also … agonist and 5-HT 2C antagonist
properties of agomelatine … nortriptyline seems to be more efficacious than either drug given …

… the clinical efficacy and safety profile of agomelatine in the … MT1/MT2 receptors (agonist
activity) and at 5HT2C receptors (… agonist and 5-HT2C antagonist properties of agomelatine may …

… does not mimic the efficacy of agomelatine [69, 93]. In an animal model, agomelatine …
that both the 5-HT2C receptor antagonist and the melatonin receptor agonist (MT1/MT2) are …