Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

SM Freeman, S Samineni, PC Allen… - …, 2016 - Elsevier
… and the peripheral vasculature following intravenous (IV) and intranasal (IN) administration
of … course of concurrent cerebrospinal fluid (CSF) and plasma samples were taken following

Effects of positive and negative human contacts and intranasal oxytocin on cerebrospinal fluid oxytocin

JL Rault - Psychoneuroendocrinology, 2016 - Elsevier
… In comparison, CSF OT concentration did not differ following intranasal saline administration
by 60 min and 120 min compared to baseline (0 min: 100% vs. 60 min: 108.7 ± 16.4% and …

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

MR Lee, KB Scheidweiler, XX Diao, F Akhlaghi… - Molecular …, 2018 - nature.com
… Although studies have shown increased cerebrospinal fluid (CSF) OT levels following IN …
Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal

Oxytocin levels in saliva correlate better than plasma levels with concentrations in the cerebrospinal fluid of patients in neurocritical care

J Martin, SM Kagerbauer, J Gempt… - Journal of …, 2018 - Wiley Online Library
oxytocin levelsafter nasal application.33, 34 Intranasal oxytocin may reach the brain using
an intraneuronal transport route via the olfactory and trigeminal nerves connecting the nasal

Intranasal oxytocin: myths and delusions

G Leng, M Ludwig - Biological psychiatry, 2016 - Elsevier
… appears to reach the cerebrospinal fluid. However, peripheral … of oxytocin from blood after
intranasal application suggests that large amounts reach an extravascular pool from which it

Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

DS Quintana, KT Smerud, OA Andreassen… - Therapeutic …, 2018 - Taylor & Francis
… that oxytocin concentrations in CSF increase after intranasaloxytocin concentrations after
intranasal oxytocin appear to be accompanied by concomitant increases in peripheral levels […

Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men

DS Quintana, LT Westlye, KT Smerud… - Hormones and …, 2018 - Elsevier
oxytocin concentrations after intranasal oxytocin were larger compared to IV administration,
we suggest that cleared exogenous oxytocin from the nasal … saliva concentrations should not …

Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration

SM Francis, MG Kirkpatrick, H de Wit… - Psychoneuroendocrinology, 2016 - Elsevier
… Our results show a measurable and significant increase in pOT and uOT levels after the …
Given the challenges, risk, and invasiveness of measuring OT in cerebrospinal fluid (csfOT), …

[HTML][HTML] A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans

Y Paloyelis, OM Doyle, FO Zelaya, S Maltezos… - Biological …, 2016 - Elsevier
… trials have explored the therapeutic value of intranasal oxytocin (IN-OT) for neuropsychiatric
… changes in the concentration of vasopressin in the cerebrospinal fluid (CSF) after intranasal

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
… [74] measured CSF concentrations of oxytocin after intranasal administration of labeled (d5-…
87] measured cerebrospinal fluid samples before and after intranasal administration of 50 μg …