A new perspective on the renin-angiotensin system

A Martyniak, PJ Tomasik - Diagnostics, 2022 - mdpi.com
… prostaglandins synthesized by the kidneys in large amounts. … of enalapril (ACEI) and LCZ696,
one of the new group drugs, … to block RAAS and augment natriuretic peptides. ARNIs have …

Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome

Y Li, L Kang, K Rong, Y Zhang, Y Suo, M Yuan, Q Bao… - Life Sciences, 2021 - Elsevier
… of the natriuretic peptide system locally in the kidneys, were … cardio-renal effects such as
diuresis, natriuresis, vasodilatation, … with sacubitril/valsartan compared with enalapril [20]. In the …

Effects of angiotensin-neprilysin inhibition in canines with experimentally induced cardiorenal syndrome

HN Sabbah, K Zhang, RC Gupta, J Xu… - Journal of cardiac …, 2020 - Elsevier
… patients receiving the ACE inhibitor enalapril. Patients treated … that NEP inhibition results
in increased levels of natriuretic … in patients with chronic kidney disease and patients with HF …

NPCdc, a synthetic natriuretic peptide, is a substrate to neprilysin and enhances blood pressure-lowering induced by enalapril in 5/6 nephrectomized rats

RS Aires, LF da Silva Filho, LFGR Ferreira… - Toxicon, 2021 - Elsevier
… in vivo whether angiotensin I-converting enzyme (ACE) inhibition would … Chronic kidney
disease (CKD) may induce progressive … , vasodilators, beta-blockers and inhibitors of the renin-…

Pharmacological effects of RAAS blockade in ischemic nephropathy

L Rivoli, F Di Mario, G Coppolino… - Current Drug …, 2016 - ingentaconnect.com
… The role of renin angiotensin aldosterone system as a mediator of … Bradykinin also causes
natriuresis through direct tubular … Renal failure due to enalapril and captopril in bilateral renal

Unraveling the pivotal role of bradykinin in ACE inhibitor activity

S Taddei, L Bortolotto - American Journal of Cardiovascular Drugs, 2016 - Springer
inhibitors of bradykinin degradation than of angiotensin II … the result of vasodilation, renal
dilation, and natriuretic effects [… salt diet, protected kidneys against salt-induced renal damage, …

Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: molecular and cellular mechanisms involved in end-organ damage during …

N Muñoz-Durango, CA Fuentes, AE Castillo… - International journal of …, 2016 - mdpi.com
… 28] the potential benefits of ACE inhibitor (captopril) in addition … through several mechanisms,
natriuresis and diuresis, neuro-… the amelioration of chronic kidney disease due to the action …

Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic

SH Ksiazek, L Hu, S Andò, M Pirklbauer… - International Journal of …, 2024 - mdpi.com
… health and kidney disease of RAAS inhibition and present … In the 90s, two trials evaluating
the ACE inhibitor captopril in … duration of natriuretic, diuretic and vasodilation effects. Given …

[PDF][PDF] Modulation of the RAA axis as a treatment for CKD

S OBAL - HILL'S - gep-central-prod.s3.eu-central-1 …
… 3, 4 The predominant effects of angiotensin II in the kidneyVasodilation, natriuresis and
reduced blood pressure may all … of inhibition of angiotensin converting enzyme with enalapril

The renin–angiotensin–aldosterone system update: full-court press

AM Provenzano, MA Sparks - Nephrology Dialysis …, 2020 - academic.oup.com
… in diabetic kidney disease, neprilysin inhibition in heart … breaks down biologically active
natriuretic peptides. Multiple … which is the angiotensin–neprilysin inhibition versus enalapril in HF …