Nanoparticles modified with cell-penetrating peptides: Conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and therapy

I Gessner, I Neundorf - International journal of molecular sciences, 2020 - mdpi.com
… versatile vehicles for the intracellular transport of various cargos, … On the other hand,
endocytosis is mainly observed when larger … fate of conjugates in comparison to their individual …

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery

S Soni, SK Kori, P Nema, AK Iyer… - Current Medicinal …, 2024 - ingentaconnect.com
… effectual intracellular transport of nanoparticles within cells … ceptor-mediated endocytosis,
and delivery vectors based on … release of cationic peptide-conjugated peptide nucleic acids …

The utilization of cell-penetrating peptides in the intracellular delivery of viral nanoparticles

J Váňová, A Hejtmánková, MH Kalbáčová… - Materials, 2019 - mdpi.com
… as nanocontainers for the efficient transport of nucleic acids (DNA… target cells and utilize
various endocytic pathways for the … delivery of a cargo [27,75], Ad with covalently conjugated Tat …

Internalization mechanisms of cell-penetrating peptides

I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
Endocytosis as a mechanism for the transport of CPPs … conjugated to nanoparticles and
perhaps macromolecules. … The future fate of these structures is not entirely clear. Viruses are …

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

ND Donahue, H Acar, S Wilhelm - Advanced drug delivery reviews, 2019 - Elsevier
Nanoparticle-based therapeutics and diagnostics are commonly referred to as nanomedicine
and may significantly impact the future … delivery of nanoparticles to specific cell populations …

Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges

A Komin, LM Russell, KA Hristova… - Advanced drug delivery …, 2017 - Elsevier
… For example, the first cell penetrating peptides (CPPs) were … , peptides conjugated to
liposomes and gold nanoparticles, … goals, peptide-cargo conjugates that are endocytosed must …

Cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, K Künnapuu, Ü Langel - Expert opinion on drug …, 2017 - Taylor & Francis
… to specific intracellular compartments by covalent conjugation to … Different endocytic pathways
could be used by CPP-cargo … the intracellular delivery of inorganic nanoparticles including …

Macropinocytosis as a cell entry route for peptide-functionalized and bystander nanoparticles

YX Li, HB Pang - Journal of Controlled Release, 2021 - Elsevier
Endocytic pathways provide the primary route for therapeutic … cell-penetrating peptides
(CPPs), a family of short peptides (… enables the conjugates to access their intracellular targets, …

Cell penetrating peptide-modified poly (lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

JM Steinbach, YE Seo, WM Saltzman - Acta biomaterialia, 2016 - Elsevier
… To conjugate CPPs to the surface of our NPs, we combined our siRNA PLGA approach with
… in the various stages of endocytosis spanning clathrin uptake, early endosome transport, to …

Combination of cell-penetrating peptides with nanoparticles for therapeutic application: a review

S Silva, AJ Almeida, N Vale - Biomolecules, 2019 - mdpi.com
… the recent conjugation of CPPs with nanoparticles, which … , after endocytosis, CPPs or
CPP-cargo conjugated are … The results demonstrated that this conjugation accelerated transport