… This study investigates the regulation of TWIK-related potassium channel-1 (Trek1… Endothelial
TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS…

… suggest that TREK-1 may act as another factor to regulate tissue … that in TREK-1 knockout
mouse model, brain endothelial cells … leukocyte trafficking into the central nervous system. …

… spinal cord potassium (TRESK) and TWIK-related potassium (TREK) … that endothelial TREK-1
function is essential for the maintenance of BBB function and the prevention of immune cell …

… K 2P 2.1 (TREK1), a two-pore domain potassium channel, … to endothelial cells as skeletal
muscle cells with impaired K 2P … for K 2P 2.1 signaling as regulator of immune cell trafficking …

… inward rectifying K + channel 1 (TWIK1) and TWIK-related K + channel 1 (TREK1, Olsen et
al… clinical symptoms and reduced immune cell infiltration into the CNS. Moreover, through the …

… by elevated CNS T cell infiltration, altered endothelium integrity, … protein, was found to regulate
TREK1 membrane trafficking by … Regulation of TWIK-related potassium channel-1 (Trek1) …

… to demonstrate that KK regulates immune cell trafficking to the CNS by modulating BBB
function. … As murine data suggest a regulatory function of PK on endothelial cells, we performed …

… TWIK-related K + channel 1 (TREK-1) potassium channel is a member of the … Endothelial
TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat …

… by elevated CNS T cell infiltration, altered endothelium integrity, … protein, was found to regulate
TREK1 membrane trafficking by … Regulation of TWIK-related potassium channel-1 (Trek1) …

… role of TWIK-related K + channel 1 (TREK-1) in global … barrier (BBB) breakdown, reduced
immune cell invasion, and better … , and endothelial cells expressed little if any TREK-1 mRNA (…