Endothelium-derived relaxing factors and endothelial function: A systematic review

F Nappi, A Fiore, J Masiglat, T Cavuoti, M Romandini… - Biomedicines, 2022 - mdpi.com
factor is compromised to varying degrees [5]. The concept that endothelial dysfunction is
NO synthase (NOS-3) and by focusing on polymorphisms in NOS-3 they demonstrated how …

Endothelium-dependent hyperpolarization: the evolution of myoendothelial microdomains

CJ Garland, KA Dora - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
Endothelium-derived hyperpolarizing factor (EDHF) was … K Ca 3.1 channels are focused
within fine myoendothelial … directed to excellent recent reviews on these specific factors. …

[HTML][HTML] Hyperpolarization and the endothelium

CJ Garland, KA Dora - Current Opinion in Physiology, 2023 - Elsevier
… examples where factors seem to play a role in initiating hyperpolarization in certain …
focused on EC-to-VSM signaling, but the nature of gap junctions means bidirectional signaling is

Endothelium‐dependent hyperpolarization: age, gender and blood pressure, do they matter?

SWS Leung, PM Vanhoutte - Acta physiologica, 2017 - Wiley Online Library
… This non-exhaustive review focuses on EDH-mediated relaxations involving IK Ca …
endothelium-derived nitric oxide on endothelium-dependent hyperpolarization (EDH)-type …

Pathogenic mechanisms of pulmonary arterial hypertension: homeostasis imbalance of endothelium-derived relaxing and contracting factors

J Zhu, L Yang, Y Jia, A Balistrieri, DR Fraidenburg… - JACC: Asia, 2022 - jacc.org
Endothelium-derived hyperpolarizing factor is the third … transient hyperpolarization and
sustained relaxation in … future research directions that should focus on the development of highly …

… of the endothelial function by acute indoxyl sulfate through declined nitric oxide and not endothelium-derived hyperpolarizing factor or vasodilator prostaglandins in …

T Matsumoto, K Takayanagi, M Kojima… - Biological and …, 2019 - jstage.jst.go.jp
factors to regulate the vascular tone. In particular, vasorelaxing factors, called
endothelium-derived relaxing factors (… study, future research should focus on the mechanisms …

Nitric oxide and endothelium‐dependent hyperpolarization mediated by hydrogen peroxide in health and disease

H Shimokawa, S Godo - Basic & Clinical Pharmacology & …, 2020 - Wiley Online Library
factors.32 Next, we will focus on endothelium-derived H 2 O 2 as an EDH factor in detail. …
Indeed, in eNOS-KO mice, CMD mediated by H 2 O 2 /EDH factor is also present associated …

Endothelium-dependent hyperpolarization (EDH) in diabetes: mechanistic insights and therapeutic implications

K Goto, T Kitazono - International journal of molecular sciences, 2019 - mdpi.com
endothelium-derived hyperpolarizing factor (EDHF) which are distinct from NO or vasodilator
prostanoids. Several factorsfocusing on the effects of statins on EDH in diabetes is still …

Endothelium

CM Boulanger - Arteriosclerosis, thrombosis, and vascular biology, 2016 - Am Heart Assoc
… 7 Current epigenetic studies focus on protein coding-genes, and it … In addition,
endothelium-derived hyperpolarizing factoris also regulated by adipokines and yet unidentified …

Endothelium-derived factors

Y Gao - Biology of Vascular Smooth Muscle: Vasoconstriction …, 2022 - Springer
… The actions and related mechanisms of these vasoactive agents are the focus of this chapter…
H 2 O 2 is also believed to be an endothelium-derived hyperpolarizing factor (EDHF) with …