… Human articular cartilage consists of three spatially distinct … matrix (ECM) compositions,
chondrocyte phenotypes, and … in articular cartilage is low, such that tissue mechanical properties …

… and possess spatially varying biochemical compositions and mechanical properties for …
gene expression and matrix composition between the osteogenic and chondrogenic layers. …

… robust cartilaginous extracellular matrix … compositions for each zone of articular cartilage,
which enabled MSCs to produce cartilage with biomimetic zonal biochemical and mechanical …

… Articular cartilage is characterized by zonal organizations containing dual gradients of
biochemical cues and mechanical … and the matrix properties of articular cartilage vary with depth …

… linked to its extracellular matrix (ECM) structure and zonal … , a result of the differential
experience of mechanical force, … of the intricacies of articular cartilage structure and function, as …

… cartilage explants that retain their native structure may … the complex collagen structure and
mechanics of articular cartilage. It is … act to replace key matrix components (eg, proteoglycans) …

… However, the majority of adult tissues have a spatially varying matrix composition and
microstructure. For example, the articular cartilage architecture is characterized by only one cell-…

… It is used extensively in cartilage and bone tissue engineering [92]. Collagen type I is a
structural … had gradient porosity and mechanical properties similar to those of AC matrices [98]. …

… spatially varying matrix compositions and mechanical … articular cartilage zonal organization
in this investigation, we expect that this platform will serve as a versatile tool for engineering …

… We developed a multi-scale finite element model of articular cartilage subjected to … detailed
cartilage ultrastructure as well as spatially varying microstructural mechanical properties of …