… To better understand the heart rate dependence of SR ion … To simulate leak, we performed
calculations with 1 of the ~50 … that underlies and supports the Ca 2+ release cycle. …

… Ca 2+ from the sarcoplasmic reticulum (SR) via the SR Ca 2+ -… an increase in Na + leak
into the cells or a reduction in Na + /… Therefore, although their underlying mechanism of action …

… of the Na + /Ca 2+ exchanger and the sarcolemmal Ca 2+ -… increased sarcoplasmic reticulum
Ca 2+ content and reduced … + leak and enhances SR Ca 2+ content, which is consistent …

… describe the collective behavior of RyRs underlying leak emergence. Regulation of cardiac
… (D) Simulations illustrating disorder leak as λ increases by 10- and 100-fold from its normal (…

… is known to increase SR Ca 2 + uptake and leak respectively. In … that an increase in SR
Ca 2 + uptake was underlying the … increased CaMKII autophosphorylation and enhanced …

… underlying the interaction of flecainide with RyR2 channels. … in Po and increase in Pb (B)
Expanded frequency amplitude … no reduction in SR Ca 2 + leak when I Na was eliminated by …

… Ca 2+ exchange across SR membranes is a key determinant of … Ca + signals undergo
fluorescence enhancement by CASQ1, we … Ca 2+ leak abatement occurred at progressively higher …

… -Ca 2+ leak via “eventless” SR-Ca 2+ release. The underlying mechanism actively stabilizes
the SR-Ca 2+ … Thus, under conditions of enhanced IP 3 ICR, we hypothesized a secondary …

… cause RYR2 Ca 2+ leak from the sarcoplasmic reticulum during … is a shared mechanism
underlying both HF and AF. … 52,53 and β-blockers improved the binding of calstabin 2 to RYR2 …

… improved haemodynamics, more efficient metabolic function … The underlying mechanism
for ageing-associated increased … However, it may have resulted via an electron-transport leak …