… Human epidermal growth factor receptor 2 (HER2) is an … (approximately 5%) of metastatic
colorectal cancer (CRC) tumors … using FISH and gene copy number variation was associated …

… As an example, HS = 100 suggests that all cancer cells are mutated; HS <100 indicates
that only a fraction of cancer cells are mutated; HS >100 implies gene copy number variation, …

… efficacy for the use of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies
(that is, cetuximab and panitumumab) in metastatic colorectal cancer patients with RAS wild-…

… Genes present in all gene panels were kept for the analyses. Frequency of genomic alterations
including mutations, copy number variations (CNVs), and gene fusions were compared …

… clinical features and EFGR gene copy number, and the present study is the first to focus on
the relationships between clinical outcome and EGFR gene copy number … gene copy number …

… Table 5 miRNA-mRNA interactions identified in non-metastatic and metastatic colorectal
patients by Pearson correlation analysis of the expression signal identified for EGFR transcripts, …

… The potential benefits from epidermal growth factor receptor monoclonal antibodies (EGFR
MAb) come at the cost of increased odds of toxicity, in particular overall grade 3 to 4 toxicity, …

… areas of GC tumors, the rate of increased gene copy number that was detected in the
tissue array slides may be lower than indicated according to the results of the present study. …

… Citation60 In contrast, the relationship between EGFR gene copy number as well as … factors,
EGFR gene copy number is difficult to apply in clinical practice regardless of KRAS status. …

… The authors reported that responses were significantly more common in tumours with high
HER2 gene copy number. Additionally, the PFS was longer in this population. Finally, the …