Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their
influence through alterations of the epigenetic landscape. Here, we review key facts on the
involvement of epigenetic modifications in allergic diseases and summarize and critically
evaluate the lessons learned from epigenome-wide association studies. We show the
potential of epigenetic changes for various clinical applications: as diagnostic tools, to …

Review Potaczek, Harb, Michel, Alashkar Alhamwe, Renz & Tost contact dermatitis, non-IgE-
mediated food allergy or intrinsic AD [15, 16]. Furthermore, different subtypes of asthma can
arise unrelated to IgE (non-atopic asthma) and although these might represent different
disease entities, they share a number of similarities including the below described cytokine
shift and resulting inflammation as well as mast cell activation [17, 18]. As many publications
studying epigenetic modifications in asthma do not provide extensive information on the type …