Retinoic acid as a modulator of T cell immunity

MR Bono, G Tejon, F Flores-Santibañez, D Fernandez… - Nutrients, 2016 - mdpi.com
… of Treg cell differentiation and effector functions [44]. … may also promote T cell activation and
T helper cell responses during … of mature CD4 + T cells that contain autoreactive T cells [95]. …

Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro

M Martínez-Blanco, D Lozano-Ojalvo… - Frontiers in …, 2021 - frontiersin.org
cells generated from CD4 + CD44 - CD62L + cells in the presence of RA to suppress effector
T cell … Figure 3B, RA promoted a much lower IL-10 expression by Foxp3 + T cells after 48 h …

Retinoic acid and immune homeostasis: a balancing act

MN Erkelens, RE Mebius - Trends in immunology, 2017 - cell.com
… molecules in T and B cells, inducing regulatory T cells (Tregs), and promoting tolerance.
However, it was suggested that RA can have a broad spectrum of effector functions depending …

Impact of retinoic acid on immune cells and inflammatory diseases

LM Oliveira, FME Teixeira… - Mediators of inflammation, 2018 - Wiley Online Library
… complex is recognized via the stimulated by retinoic acid 6 (… role in promoting effector T cell
response in the gut [36, 49]. … -β promote the generation of Tregs from naïve CD4 T cells by …

Retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system

A Larange, H Cheroutre - Annual review of immunology, 2016 - annualreviews.org
… Rara −/− CD4 T cells or in wild-type CD4 T cells treated with the pan-… by effector and memory
T cells, which promote effector … antibody responses against T cell–dependent antigens such …

[HTML][HTML] Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8+ T cell-mediated immunity in colorectal cancer

N Bhattacharya, R Yuan, TR Prestwood, HL Penny… - Immunity, 2016 - cell.com
… We hypothesized that a local deficiency of atRA might promote … -tumor effect of atRA mediated
through CD8 + effector T cells. … Although mature CD4 + T cells can be reprogrammed in an …

Control of innate and adaptive lymphocytes by the RAR-retinoic acid axis

CH Kim - Immune Network, 2018 - synapse.koreamed.org
… For example, RAs promote effector T cell maintenance, … T cells sense antigens through their
T cell receptors (TCRs) and … cells among intestinal CD4+ T cells (15). During active immune …

Retinoic acid–responsive CD8 effector T cells are selectively increased in IL-23–rich tissue in gastrointestinal GVHD

JA Ball, A Clear, J Aries, S Charrot… - Blood, The Journal …, 2021 - ashpublications.org
… FOXP3 + CD4 T cells using sequential immunostaining. … IL-23, which modulates T-cell
responses to RA in other contexts … on CD8 effector T cells and regulatory CD4 T cells to promote

LZTFL1 upregulated by all-trans retinoic acid during CD4+ T cell activation enhances IL-5 production

H Jiang, K Promchan, BR Lin, S Lockett… - The Journal of …, 2016 - journals.aai.org
Retinoic acids, which are metabolites of vitamin A, have been … T cell effector responses
through their binding to the retinoicEssential role for retinoic acid in the promotion of CD4(+) T

Topical treatment of all‐trans retinoic acid inhibits murine melanoma partly by promoting CD8+ Tcell immunity

W Yin, Y Song, Q Liu, Y Wu, R He - Immunology, 2017 - Wiley Online Library
promoted the differentiation of effector CD8 + T cells in draining lymph nodes (DLN) of
tumour-bearing mice. Interestingly, atRA did not affect tumoral CD4 + T-cell response, … through the …