Oestrogen receptor β activation protects against myocardial infarction via Notch1 signalling

M Du, J Shan, A Feng, S Schmull, J Gu… - Cardiovascular Drugs and …, 2020 - Springer
… cardiac function improvement. Ischaemic injury–induced … mechanisms of oestrogen receptor
β/Notch1 signallingmediated … the PI3K/Akt pathway during oestrogen receptor β activation, …

[HTML][HTML] G protein-coupled estrogen receptor 1 inhibits angiotensin II-induced cardiomyocyte hypertrophy via the regulation of PI3K-Akt-mTOR signalling and …

H Pei, W Wang, D Zhao, H Su, G Su… - International Journal of …, 2019 - ncbi.nlm.nih.gov
… of stress, such as myocardial infarction and pressure overload, … cardiomyocytes may be
mediated by its downregulation of … cardiomyocytes improves our understanding of how estrogen

E2/ER β enhances calcineurin protein degradation and PI3K/Akt/MDM2 signal transduction to inhibit ISO-induced myocardial cell apoptosis

KH Lin, WW Kuo, MA Shibu, CH Day, YL Hsieh… - International journal of …, 2017 - mdpi.com
… ERβ in the PI3K/Akt/MDM2 mediated calcineurin degradation, … using β-AR blockers not only
efficiently improve the cardiac … that PI3K-Akt-MDM2 signaling activation is estrogen receptor β

Activation of PI3K/Akt pathway mediated by estrogen receptors accounts for estrone-induced vascular activation of cGMP signaling

TS de Oliveira, LM de Oliveira, LP de Oliveira… - Vascular …, 2018 - Elsevier
… relaxation through classic estrogen receptors activation on the endothelium. We also identify
CaM and PI3K/Akt pathways as critical mediators of the NO-cGMP signaling activation by E1…

Estrogen receptors: therapeutic perspectives for the treatment of cardiac dysfunction after myocardial infarction

JS da Silva, TL Montagnoli, BS Rocha… - International journal of …, 2021 - mdpi.com
Estrogen receptors (ER) mediate functions beyond their … In a MI model in male mice,
activation of the ERα/PI3K/Akt/… and serum cardiac markers and improved cardiac function [81]. …

… up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling …

X Yang, X Mao, G Xu, S Xing, A Chattopadhyay, S Jin… - Heart Rhythm, 2018 - Elsevier
… classic genomic mechanism mediated by estrogen receptor-α (… E2 incubation increased
p-CREB via the Pi3K/Akt pathway, … response of the myocardium to pathophysiological conditions…

GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway

X Wang, L Lu, Y Tan, L Jiang, M Zhao, E Gao, S Yu… - Life sciences, 2019 - Elsevier
… , is a new estrogen receptor (ER) that binds estrogen with high … improve cardiac function in
female OVX mice by activating … may mediate myocardial protective effects through PI3K/AKT. …

Diosgenin attenuates myocardial cell apoptosis triggered by oxidative stress through estrogen receptor to activate the PI3K/Akt and ERK axes

MYC Chen, BCK Tsai, WW Kuo, CH Kuo… - The American Journal …, 2023 - World Scientific
… Our findings indicate that diosgenin activates the PI3K-AKT and MEK/ERK signaling axes …
β -Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated

The role of estrogen receptors in cardiovascular disease

L Aryan, D Younessi, M Zargari, S Banerjee… - International journal of …, 2020 - mdpi.com
… The G1-mediated cardioprotection is mediated by the activation of the PI3K/Akt pathway, and
… Tissue Doppler studies showed that G1 administration improved myocardial relaxation in …

Interplay between PI3K/AKT pathway and heart disorders

S Ghafouri-Fard, A Khanbabapour Sasi… - Molecular biology …, 2022 - Springer
… , PI3K/AKT pathway participates in the process of myocardial … LDH, improve energy metabolism
and relieve myocardial injury. … damage via mediating the PI3K/AKT/Nrf-2 pathway [67]. …