[HTML][HTML] Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice

A Martín-Belmonte, C Aguado, R Alfaro-Ruiz… - Alzheimer's research & …, 2022 - Springer
… the oligomeric Aβ42 induced an upregulation of GIRK channel … provide novel evidence for
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABA B receptors in …

Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling

M Terunuma - Proceedings of the Japan Academy, Series B, 2018 - jstage.jst.go.jp
… There is also some evidence suggesting that GABAB receptors inhibit N-type and …
oligomerization of GABAB receptors with GIRK channels (GIRK1 and GIRK3) has also been reported.…

Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling

TR Rose, K Wickman - Behavioral Neurobiology of GABAB Receptor …, 2020 - Springer
… depending on the oligomeric state of the GABA B R – … is evidence that GABA B Rs, G
proteins, and GIRK channelsbetween GABA B Rs and GIRK2 homotetramers, GIRK1/4 or …

[HTML][HTML] Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid-β Pathology

I Sánchez-Rodríguez, A Gruart… - International journal of …, 2019 - mdpi.com
Evidence suggests that an increase in GirK-dependent signaling is … oligomers [62,63]
present in early stages of AD. ML297, a specific activator of GIRK1-containing GirK channels, was …

[HTML][HTML] G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid β toxicity

LM May, V Anggono, HM Gooch, SE Jang… - Frontiers in …, 2017 - frontiersin.org
… Excitotoxic oligomeric Aβ 42 upregulates GIRK channel surface … (E) of total and surface
GIRK1 and GIRK2 protein levels in … of GABA B receptors, which are tightly coupled to GIRK

[HTML][HTML] Differential association of GABAB receptors with their effector ion channels in Purkinje cells

R Luján, C Aguado, F Ciruela, J Cozar… - Brain Structure and …, 2018 - Springer
… There is now substantial evidence showing that GABA B receptors, … , GABA B receptor/GIRK
channel, GABA B receptor/Ca V 2.1 … the idea that these oligomeric complexes might have …

[HTML][HTML] Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β …

I Sánchez-Rodríguez, S Temprano-Carazo, A Nájera… - Scientific Reports, 2017 - nature.com
GIRK1-containing heterotetramers 54,55 . Available evidence suggests that enhanced GirK-…
room temperature before injection to form soluble oligomers and not fibrils according to the …

[HTML][HTML] The expression and localisation of G-protein-coupled inwardly rectifying potassium (GIRK) channels is differentially altered in the hippocampus of two mouse …

R Alfaro-Ruiz, A Martín-Belmonte, C Aguado… - International Journal of …, 2021 - mdpi.com
GIRK channel in the brain consists primarily of GIRK1 and … dysfunction caused by Aβ
oligomers ultimately results in NFT … Consistent with our results, evidence from immunoelectron …

[PDF][PDF] Nanoscale alterations in GABA

A Martín‑Belmonte, C Aguado, R Alfaro‑Ruiz… - 2022 - alzres.biomedcentral.com
… the oligomeric Aβ42 induced an upregulation of GIRK channel … provide novel evidence for
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABAB receptors in …

[HTML][HTML] Preassembly of specific Gβγ subunits at GABAB receptors through auxiliary KCTD proteins accelerates channel gating

T Fritzius, R Tureček, D Fernandez-Fernandez… - Biochemical …, 2024 - Elsevier
… would involve a transient complex between Gα and the KCTD-bound Gβγ. Co-IP of Gα with
the KCTDs in the presence of Gβγ provides experimental evidence for the existence of such …