[HTML][HTML] Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice
A Martín-Belmonte, C Aguado, R Alfaro-Ruiz… - Alzheimer's research & …, 2022 - Springer
… the oligomeric Aβ42 induced an upregulation of GIRK channel … provide novel evidence for
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABA B receptors in …
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABA B receptors in …
Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling
M Terunuma - Proceedings of the Japan Academy, Series B, 2018 - jstage.jst.go.jp
… There is also some evidence suggesting that GABAB receptors inhibit N-type and …
oligomerization of GABAB receptors with GIRK channels (GIRK1 and GIRK3) has also been reported.…
oligomerization of GABAB receptors with GIRK channels (GIRK1 and GIRK3) has also been reported.…
Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling
TR Rose, K Wickman - Behavioral Neurobiology of GABAB Receptor …, 2020 - Springer
… depending on the oligomeric state of the GABA B R – … is evidence that GABA B Rs, G
proteins, and GIRK channels … between GABA B Rs and GIRK2 homotetramers, GIRK1/4 or …
proteins, and GIRK channels … between GABA B Rs and GIRK2 homotetramers, GIRK1/4 or …
[HTML][HTML] Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid-β Pathology
I Sánchez-Rodríguez, A Gruart… - International journal of …, 2019 - mdpi.com
… Evidence suggests that an increase in GirK-dependent signaling is … oligomers [62,63]
present in early stages of AD. ML297, a specific activator of GIRK1-containing GirK channels, was …
present in early stages of AD. ML297, a specific activator of GIRK1-containing GirK channels, was …
[HTML][HTML] G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid β toxicity
LM May, V Anggono, HM Gooch, SE Jang… - Frontiers in …, 2017 - frontiersin.org
… Excitotoxic oligomeric Aβ 42 upregulates GIRK channel surface … (E) of total and surface
GIRK1 and GIRK2 protein levels in … of GABA B receptors, which are tightly coupled to GIRK …
GIRK1 and GIRK2 protein levels in … of GABA B receptors, which are tightly coupled to GIRK …
[HTML][HTML] Differential association of GABAB receptors with their effector ion channels in Purkinje cells
… There is now substantial evidence showing that GABA B receptors, … , GABA B receptor/GIRK
channel, GABA B receptor/Ca V 2.1 … the idea that these oligomeric complexes might have …
channel, GABA B receptor/Ca V 2.1 … the idea that these oligomeric complexes might have …
[HTML][HTML] Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β …
I Sánchez-Rodríguez, S Temprano-Carazo, A Nájera… - Scientific Reports, 2017 - nature.com
… GIRK1-containing heterotetramers 54,55 . Available evidence suggests that enhanced GirK-…
room temperature before injection to form soluble oligomers and not fibrils according to the …
room temperature before injection to form soluble oligomers and not fibrils according to the …
[HTML][HTML] The expression and localisation of G-protein-coupled inwardly rectifying potassium (GIRK) channels is differentially altered in the hippocampus of two mouse …
R Alfaro-Ruiz, A Martín-Belmonte, C Aguado… - International Journal of …, 2021 - mdpi.com
… GIRK channel in the brain consists primarily of GIRK1 and … dysfunction caused by Aβ
oligomers ultimately results in NFT … Consistent with our results, evidence from immunoelectron …
oligomers ultimately results in NFT … Consistent with our results, evidence from immunoelectron …
[PDF][PDF] Nanoscale alterations in GABA
A Martín‑Belmonte, C Aguado, R Alfaro‑Ruiz… - 2022 - alzres.biomedcentral.com
… the oligomeric Aβ42 induced an upregulation of GIRK channel … provide novel evidence for
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABAB receptors in …
the specific reduction of GIRK1/… for the uncoupling of GIRK channels and GABAB receptors in …
[HTML][HTML] Preassembly of specific Gβγ subunits at GABAB receptors through auxiliary KCTD proteins accelerates channel gating
T Fritzius, R Tureček, D Fernandez-Fernandez… - Biochemical …, 2024 - Elsevier
… would involve a transient complex between Gα and the KCTD-bound Gβγ. Co-IP of Gα with
the KCTDs in the presence of Gβγ provides experimental evidence for the existence of such …
the KCTDs in the presence of Gβγ provides experimental evidence for the existence of such …