Antidepressants promote formation of heterocomplexes of dopamine D2 and somatostatin subtype 5 receptors in the mouse striatum

K Szafran-Pilch, A Faron-Górecka, M Kolasa… - Brain Research …, 2017 - Elsevier
receptors heterodimers. These findings provide interesting evidence that dopamine D2 and
somatostatin Sst5 heterodimers may be considered as potential mediators of antidepressant …

Somatostatin, a presynaptic modulator of glutamatergic signal in the central nervous system

A Pittaluga, A Roggeri, G Vallarino… - International Journal of …, 2021 - mdpi.com
… innervating the septum, the striatum, the hippocampus and the … somatostatin immunoreactivity
was high, the sst2 receptorsevidence was published demonstrating that somatostatin

A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders

SL Robinson, TE Thiele - Neuropharmacology, 2020 - Elsevier
… We further summarize evidence of a direct role for the SST … observed in this study was
mediated by an increase in CeA SST … infusion increases striatal dopamine release via presynaptic …

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

A Faron-Górecka, M Kuśmider, J Solich, M Kolasa… - …, 2018 - Springer
… R in the stress response, we decided to examine the role of sst 2 … role of stress in the levels
of DA in the PFc and striatum, with a … , providing further evidence that this group is overactive. …

Functional mapping of somatostatin receptors in brain: in vivo microdialysis studies

A Kastellakis, J Radke, K Thermos - In Vivo Neuropharmacology and …, 2017 - Springer
… further evidence suggesting that the sst 2 receptor is … showing that the sst 1 receptor mediates
the inhibitory actions of … This study [82] provided conclusive evidence to support that the …

Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models

B Scheich, B Gaszner, V Kormos, K László, C Ádori… - …, 2016 - Elsevier
… 2), which provides evidence that separate breeding does not … by the sst 2 receptor activation,
because only the sst 2 agonist … hippocampal somatostatin sst 3 and sst 4 receptors mediate

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles

MCA Coelho, ML Vasquez, LE Wildemberg… - Scientific Reports, 2019 - nature.com
sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin
receptor … , where it acts as a key mediator of cytoskeleton reorganization 11 . FLNA binds …

Structure and Function of Somatostatin and its Receptors in Endocrinology

B Zhang, L Xue, ZB Wu - Endocrine Reviews, 2024 - academic.oup.com
… with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory
… Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive …

Somatostatin and Neurotensin Systems in Schizophrenia

A Induni, F Gil Zbinden, MG López Ordieres - Psychiatry and Neuroscience …, 2021 - Springer
receptors mediate the inhibition of insulin secretion, and the sst2 receptor seems to mediate
… a culture of dopaminergic neurons, it has been enabled to prove a bidirectional interaction …

Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior

DF Brockway, KR Griffith, CM Aloimonos, TT Clarity… - Cell reports, 2023 - cell.com
We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex
in mice. We performed slice electrophysiology in pyramidal and GABAergic neurons to …