Tracking the origin, development, and differentiation of hematopoietic stem cells

PR Dharampuriya, G Scapin, C Wong… - Current opinion in cell …, 2017 - Elsevier
… in lineage tracing for the hematopoietic system, as well as … hematopoiesis and cell fate
mapping at a single-cell level. … , their gene expression varied, as ∼50% of the cells expressed

Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment

M De Grandis, AC Lhoumeau, SJC Mancini… - Cellular and molecular …, 2016 - Springer
at specific stage of differentiation to regulate hematopoieticadhesion between cells of a
single type or heterophilic … Tie2 receptor, expressed on endothelium and on hematopoietic

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

Y Zeng, J He, Z Bai, Z Li, Y Gong, C Liu, Y Ni, J Du… - Cell research, 2019 - nature.com
… We further mapped the developmental path from arterial ECs … the expression of hematopoietic
and endothelial genes. d … leukocyte cell-cell adhesion and differentiation were enriched in …

Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture

S Liu, DF Stroncek, Y Zhao, V Chen, R Shi… - Journal of translational …, 2019 - Springer
… 3D Diffusion map visualization of single BMSCs from passages … in a and the expression of
hematopoietic cell markers in CD45… We also investigated the expression of Vascular Adhesion

[HTML][HTML] Dynamic gene regulatory networks drive hematopoietic specification and differentiation

DK Goode, N Obier, MS Vijayabaskar, M Lie-A-Ling… - Developmental cell, 2016 - cell.com
… defined by their individual gene expression programs and are … global gene expression profiles
by RNA-seq and mapped … relating to vasculogenesis and adhesion, whereas pattern E20 …

Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics

B Hadland, B Varnum-Finney, S Dozono… - Nature …, 2022 - nature.com
… formation of long-term engrafting hematopoietic stem cells (… with integrins and cell adhesion
receptors, cytokines/chemokines, … a comprehensive transcriptional map of HSC development …

Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell RNA-sequencing

X Han, H Chen, D Huang, H Chen, L Fei, C Cheng… - Genome biology, 2018 - Springer
… 3D EBs have complex cell adhesions and paracrine signaling … We used hematopoietic
differentiation system to compare the … FOS can induce the expression of hematopoietic genes [89]. …

Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

A Roch, S Giger, M Girotra, V Campos… - Nature …, 2017 - nature.com
… a Heat-map of expression of 24 genes (Ct values) for freshly … To understand the cell–cell
interaction and adhesion of … differentiation fate choices. Here, we employed a combination of …

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

A Maiga, S Lemieux, C Pabst, VP Lavallée… - Blood Cancer …, 2016 - nature.com
… .2 package and Eland v2 mapping software and bioinformatic … and blood hematopoietic
cells. Accordingly, we analyzed the … Adhesion GPCRs are a family of receptors characterized by …

A 3D atlas of hematopoietic stem and progenitor cell expansion by multi-dimensional RNA-seq analysis

Y Xue, D Liu, G Cui, Y Ding, D Ai, S Gao, Y Zhang… - Cell reports, 2019 - cell.com
… organ in which HSPCs expand and differentiate. Employing transgenic embryos, … , genes
specifically expressed in HSPCs at 36 hpf were mostly enriched in the GO terms “cell adhesion” …