Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer

C Stirzaker, JZ Song, W Ng, Q Du, NJ Armstrong… - Oncogene, 2017 - nature.com
… that MBD2 mRNA and protein expression was reduced by 60… methylation and a decrease
in de novo methylation, we next determined if MBD2 is associated with DNA methyltransferase

Methyl CpG binding protein 2 promotes colorectal cancer metastasis by regulating N6‐methyladenosine methylation through methyltransferase‐like 14

S Wang, M Gan, C Chen, Y Zhang, J Kong… - Cancer …, 2021 - Wiley Online Library
… To further determine the biological roles of MeCP2 in CRC, we detected the protein and
mRNA expression of MeCP2 in six CRC cell lines (Figure S1). Then shRNA was used to knock …

Alterations in DNA methyltransferases and methyl-CpG binding domain proteins during cleft palate formation as induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in …

W Zhang, S Zhou, Y Gao, H Song… - Molecular …, 2018 - spandidos-publications.com
… specific proteins, called methyl-CpG binding domain proteins (… palate patients usually show
distinct methylation profiles (12), … mRNA expression of methyl-CpG binding domain proteins

Cys2His2 zinc finger methyl-CpG binding proteins: getting a handle on methylated DNA

AJ Hodges, NO Hudson, BA Buck-Koehntop - Journal of Molecular Biology, 2020 - Elsevier
… number of disease conditions, DNA methylation patterns are … In addition to controlling gene
expression, DNA methylation also … Furthermore, elevated ZBTB4 mRNA levels coincided with …

[HTML][HTML] Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer

TW Kim, SJ Lee, BM Oh, H Lee, TG Uhm, JK Min… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… , MBD2, MBD3, and methyl-CpG binding protein 2 (MeCP2) … TLR4 expression may be
silenced by promoter methylation in … of SNU-668 cells with DNA methyltransferase inhibitor 5-aza-…

MethylCpGbinding protein (MBD) family: epigenomic read‐outs functions and roles in tumorigenesis and psychiatric diseases

CO Gigek, ES Chen, MAC Smith - Journal of cellular …, 2016 - Wiley Online Library
… isoform 1 is expressed in all tissues, with lowest mRNA levels in … CpG DNA methyltransferase
1 Enhanced tumor formation. … DNA methylation to transcriptional repression by binding to …

Gene expression, DNA methylation and prognostic significance of DNA repair genes in human bladder cancer

A Wojtczyk-Miaskowska, M Presler… - Cellular Physiology and …, 2017 - karger.com
… suggest that DNMT1 mRNA and MLH1 mRNA expression, as … (methyl-CpG-binding domain
protein 4) and thymine DNADNA methyltransferase 1 protein overexpression resulting in …

The genomic impact of DNA CpG methylation on gene expression; relationships in prostate cancer

MD Long, DJ Smiraglia, MJ Campbell - Biomolecules, 2017 - mdpi.com
… DNMT1 is the major DNA methyltransferase expressed at … proteins containing the
methyl-CpG-binding-domain, known collectively as MBDs. These proteins Methyl-CpG Binding

… of an electrochemical detection system for measuring DNA methylation levels using methyl CpG-binding protein and glucose dehydrogenase-fused zinc finger protein

J Lee, W Yoshida, K Abe, K Nakabayashi… - Biosensors and …, 2017 - Elsevier
… Such methylation regulates gene expression by directly preventing a binding of a transcription
… or mRNA, it is easy to process and to obtain reproducible results. Secondly, detailed …

… -Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases …

S Xiao, S Guo, J Han, Y Sun, M Wang… - Nucleic Acids …, 2022 - academic.oup.com
… , DNA methylation is regulated by DNA methyltransferases and … , including RNA processing,
mRNA decay, and translation … Methyl-CpG-binding domain (MBD) family proteins were …