Metal sensing by the IRT1 transporter-receptor orchestrates its own degradation and plant metal nutrition

G Dubeaux, J Neveu, E Zelazny, G Vert - Molecular cell, 2018 - cell.com
… plants to tightly control the abundance of IRT1, ensuring optimal … IRT1 acts as a transceptor,
directly sensing non-iron metals … , we used transgenic plants expressing the functional IRT1-…

The bifunctional transporter‐receptor IRT 1 at the heart of metal sensing and signalling

V Cointry, G Vert - New Phytologist, 2019 - Wiley Online Library
control of IRT1 by its various metalsIRT1 transcription in response to low iron is dually
controlled by local and long-distance signals (red arrows) to allow IRT1 gene expression in roots. …

Differential metal sensing and metal‐dependent degradation of the broad spectrum root metal transporter IRT1

J Spielmann, V Cointry, F Devime, S Ravanel… - The Plant …, 2022 - Wiley Online Library
metals or 50 μm Cd, we reproducibly observed reduced IRT1-… transgenic lines expressing
IRT1 or IRT1 4HA under control of … Fe is the primary substrate of IRT1, since IRT1 transcription

The high-affinity metal transporters NRAMP1 and IRT1 team up to take up iron under sufficient metal provision

L Castaings, A Caquot, S Loubet, C Curie - Scientific reports, 2016 - nature.com
… and NRAMP1 have a broad range of substrates among metals, … Transcripts levels are
expressed relative to those of the … roots, we tested whether IRT1 expressed under the control of the …

Root‐to‐shoot iron partitioning in Arabidopsis requires IRON‐REGULATED TRANSPORTER1 (IRT1) protein but not its iron (II) transport function

J Quintana, M Bernal, M Scholle… - The Plant …, 2022 - Wiley Online Library
… Note that in our transgenic irt1 lines, IRT1 transcript levels … FER1 expression in irt1 H232A
under control conditions was … of secondary substrate metals in the irt1 mutant by comparison to …

Enhanced Cadmium Accumulation and Tolerance in Transgenic Hairy Roots of Solanum nigrum L. Expressing Iron-Regulated Transporter Gene IRT1

P Ye, M Wang, T Zhang, X Liu, H Jiang, Y Sun… - Life, 2020 - mdpi.com
… the transgenic hairy roots compared to the control (886.8 μg/g vs… homeostasis and transporting
different metals in cells. The … transcription level under Cd stress [6]. Plants overexpressing …

Mitigating cadmium accumulation in dicotyledonous vegetables by iron fertilizer through inhibiting Fe transporter IRT1-mediated Cd uptake

ZR Xu, TT You, WY Liu, K Ye, FJ Zhao, P Wang - Chemosphere, 2024 - Elsevier
IRT1 from dicotyledonous vegetables expressed in yeast, and (iii) we examined the effect of
soil pH on soil Fe availability and root IRT1 expression levels … negative and positive control, …

Comparative transcriptome analysis reveals gene network regulating cadmium uptake and translocation in peanut roots under iron deficiency

C Chen, Q Cao, Q Jiang, J Li, R Yu, G Shi - BMC plant biology, 2019 - Springer
… that metal transporter genes such as CAX4, COPT1, IRT1, … deficiency-induced expression
of Fe 2+ transporter genes may … of Fragments Per Kilobase of transcript sequence per Millions …

Comparative transcriptome analysis reveals key genes responsible for the homeostasis of iron and other divalent metals in peanut roots under iron deficiency

Q Cao, C Xv, Q Jiang, L Wang, G Shi - Plant and Soil, 2019 - Springer
… in plants is controlled by several processes, … expression of AHA2, FRO2 and IRT1 is
regulated by FIT (FER-like iron-deficiency-induced transcription factor), a bHLH transcription

The iron‐regulated transporter 1 plays an essential role in uptake, translocation and grain‐loading of manganese, but not iron, in barley

L Long, DP Persson, F Duan, K Jørgensen… - New …, 2018 - Wiley Online Library
… We also document that HvIRT1 controlled the Mn distribution … We conclude that the barley
IRT1 orthologue has a novel … We investigated the transcript expression pattern of HvIRT1 in …