DNA methylation in huntington's disease
N Zsindely, F Siági, L Bodai - International Journal of Molecular Sciences, 2021 - mdpi.com
… large gene that spans a 170 kb genomic region, contains 67 exons, and encodes a 3144
amino acid long, 348 kDa Huntingtin … Mutant Huntingtin modulates the level or activity of …
amino acid long, 348 kDa Huntingtin … Mutant Huntingtin modulates the level or activity of …
DNA methylation in Huntington's disease: Implications for transgenerational effects
EA Thomas - Neuroscience letters, 2016 - Elsevier
… Mutant huntingtin protein (mHtt) is known to … DNA methylation is extensive, and several
excellent reviews have been previously published, as will be indicated below. A comprehensive …
excellent reviews have been previously published, as will be indicated below. A comprehensive …
DNA methylation profiling in human Huntington's disease brain
RAG De Souza, SA Islam, LM McEwen… - Human molecular …, 2016 - academic.oup.com
… tissue represents the first comprehensive assessment of DNA methylation variation in human
… previous findings showing considerable levels of inter-individual expression variation in …
… previous findings showing considerable levels of inter-individual expression variation in …
Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity
Y Pan, T Daito, Y Sasaki, YH Chung, X Xing… - Scientific reports, 2016 - nature.com
… Thus, disturbances in DNA methylation play a critical role in mutant Htt-induced neuronal …
to attract considerable attention. Emerging evidence suggests that DNA methylation-mediated …
to attract considerable attention. Emerging evidence suggests that DNA methylation-mediated …
DNA methylation study of Huntington's disease and motor progression in patients and in animal models
AT Lu, P Narayan, MJ Grant, P Langfelder… - Nature …, 2020 - nature.com
… by profound changes of DNA methylation levels in three … whether HD is associated with
significant DNAm changes in other … We generate large methylation datasets from three species …
significant DNAm changes in other … We generate large methylation datasets from three species …
[HTML][HTML] DNA methylation profiles in whole blood of Huntington's disease patients
… low number of samples and the large number of simultaneously examined CpG sites (27,578),
our results are consistent with recent findings showing no change in the overall or global (…
our results are consistent with recent findings showing no change in the overall or global (…
[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
… that normal aging modulates the neurotoxicity of mutant huntingtin [12]. Future studies could
… that HD pathogenesis is associated with large scale DNA methylation changes and with an …
… that HD pathogenesis is associated with large scale DNA methylation changes and with an …
[HTML][HTML] DNA methylation leads to DNA repair gene down-regulation and trinucleotide repeat expansion in patient-derived huntington disease cells
PA Mollica, JA Reid, RC Ogle, PC Sachs… - The American journal of …, 2016 - Elsevier
… indicating that HD and DNA repair are associated, no comprehensive model has been …
of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice …
of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice …
Dynamic regulation of DNA methylation and brain functions
J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
… A comprehensive understanding of dynamic DNA methylation changes during development
… (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Identification of aberrant …
… (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Identification of aberrant …
DNA methylation in Parkinson's disease
U Wüllner, O Kaut, L deBoni, D Piston… - Journal of …, 2016 - Wiley Online Library
… as RNA editing and RNA methylation comprise considerable challenges for neuroscience
… with components of the epigenetic machinery: huntingtin directly interacts with the HAT creb …
… with components of the epigenetic machinery: huntingtin directly interacts with the HAT creb …