… large gene that spans a 170 kb genomic region, contains 67 exons, and encodes a 3144
amino acid long, 348 kDa Huntingtin … Mutant Huntingtin modulates the level or activity of …

… Mutant huntingtin protein (mHtt) is known to … DNA methylation is extensive, and several
excellent reviews have been previously published, as will be indicated below. A comprehensive …

… tissue represents the first comprehensive assessment of DNA methylation variation in human
… previous findings showing considerable levels of inter-individual expression variation in …

… Thus, disturbances in DNA methylation play a critical role in mutant Htt-induced neuronal …
to attract considerable attention. Emerging evidence suggests that DNA methylation-mediated …

… by profound changes of DNA methylation levels in three … whether HD is associated with
significant DNAm changes in other … We generate large methylation datasets from three species …

… low number of samples and the large number of simultaneously examined CpG sites (27,578),
our results are consistent with recent findings showing no change in the overall or global (…

… that normal aging modulates the neurotoxicity of mutant huntingtin [12]. Future studies could
… that HD pathogenesis is associated with large scale DNA methylation changes and with an …

… indicating that HD and DNA repair are associated, no comprehensive model has been …
of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice …

… A comprehensive understanding of dynamic DNA methylation changes during development
… (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Identification of aberrant …

… as RNA editing and RNA methylation comprise considerable challenges for neuroscience
… with components of the epigenetic machinery: huntingtin directly interacts with the HAT creb …