DNA methylation in huntington's disease

N Zsindely, F Siági, L Bodai - International Journal of Molecular Sciences, 2021 - mdpi.com
large gene that spans a 170 kb genomic region, contains 67 exons, and encodes a 3144
amino acid long, 348 kDa HuntingtinMutant Huntingtin modulates the level or activity of …

DNA methylation in Huntington's disease: Implications for transgenerational effects

EA Thomas - Neuroscience letters, 2016 - Elsevier
Mutant huntingtin protein (mHtt) is known to … DNA methylation is extensive, and several
excellent reviews have been previously published, as will be indicated below. A comprehensive

DNA methylation profiling in human Huntington's disease brain

RAG De Souza, SA Islam, LM McEwen… - Human molecular …, 2016 - academic.oup.com
… tissue represents the first comprehensive assessment of DNA methylation variation in human
… previous findings showing considerable levels of inter-individual expression variation in …

Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity

Y Pan, T Daito, Y Sasaki, YH Chung, X Xing… - Scientific reports, 2016 - nature.com
… Thus, disturbances in DNA methylation play a critical role in mutant Htt-induced neuronal …
to attract considerable attention. Emerging evidence suggests that DNA methylation-mediated …

DNA methylation study of Huntington's disease and motor progression in patients and in animal models

AT Lu, P Narayan, MJ Grant, P Langfelder… - Nature …, 2020 - nature.com
… by profound changes of DNA methylation levels in three … whether HD is associated with
significant DNAm changes in other … We generate large methylation datasets from three species …

[HTML][HTML] DNA methylation profiles in whole blood of Huntington's disease patients

M Zadel, A Maver, A Kovanda, B Peterlin - Frontiers in Neurology, 2018 - frontiersin.org
… low number of samples and the large number of simultaneously examined CpG sites (27,578),
our results are consistent with recent findings showing no change in the overall or global (…

[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

S Horvath, P Langfelder, S Kwak, J Aaronson… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
… that normal aging modulates the neurotoxicity of mutant huntingtin [12]. Future studies could
… that HD pathogenesis is associated with large scale DNA methylation changes and with an …

[HTML][HTML] DNA methylation leads to DNA repair gene down-regulation and trinucleotide repeat expansion in patient-derived huntington disease cells

PA Mollica, JA Reid, RC Ogle, PC Sachs… - The American journal of …, 2016 - Elsevier
… indicating that HD and DNA repair are associated, no comprehensive model has been …
of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice …

Dynamic regulation of DNA methylation and brain functions

J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
… A comprehensive understanding of dynamic DNA methylation changes during development
… (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Identification of aberrant …

DNA methylation in Parkinson's disease

U Wüllner, O Kaut, L deBoni, D Piston… - Journal of …, 2016 - Wiley Online Library
… as RNA editing and RNA methylation comprise considerable challenges for neuroscience
… with components of the epigenetic machinery: huntingtin directly interacts with the HAT creb …