… As development proceeds the Schwann cells proliferate and … to inhibit DNA synthesis in
routinely used Schwann cell … When grown in the absence of axons, Schwann cells dedifferentiate…

… the progression of Wallerian degeneration and axon regeneration … — pharmacological
inhibition mouse models Aim 2.2.1 … crucial for Schwann cell de- differentiation into Schwann cell …

… phagocytized in a process called Wallerian degeneration (WD), even … surviving Schwann
cells promptly undergo dedifferentiation … These findings call decades of 2D ex vivo and in vitro …

… mutations that protect against Wallerian degeneration (Mack … plasma membrane, closely
apposed at both intracellular and … In the PNS, Schwann cells form the basal lamina that bridges …

… depletion and Schwann cell transplantation hypothesizing … demonstrated by their inhibition
of axon growth in vitro [94, 95… Following injury, Schwann cells dedifferentiate via a process …

… knowledge of non-myelinating Schwann cells in the spleen (… are protected against Wallerian
degeneration after nerve injury. … through a complex de-differentiation process and cell-type …

… tances and through varying extracellular microenvironments. … Schwann cells are the
principle glial cells of the PNS, while … excess proliferation and invasion by Schwann cells and …

… coculture of motor neurons and Schwann cells over 40 days. In … segmental demyelination,
Wallerian degeneration, and distal … the dedifferentiation of SCs and decrease in intracellular …

… Nogo-A, OMgp and MAG can individually inhibit neurite … before degeneration), Schwann
cells dedifferentiate, proliferate, … debris and an incomplete Wallerian degeneration. In addition, …

… cells: Schwann cells and macrophages. One major event in this process is Wallerian
degeneration … gliaoligodendrocytes, is not able to dedifferentiate and acquire phagocytic …