Extraintestinal manifestations of inflammatory bowel disease: epidemiology, etiopathogenesis, and management

A Garber, M Regueiro - Current gastroenterology reports, 2019 - Springer
A Garber, M Regueiro
Current gastroenterology reports, 2019•Springer
Abstract Purpose of Review Extraintestinal manifestations (EIMs) of inflammatory bowel
disease (IBD) represent a complex array of disease processes with variable epidemiologic
penetrance, genetic antecedents, and phenotypic presentations. The purpose of this review
is to provide an overview of primary and secondary EIMs as well as salient treatment
strategies utilized. Recent Findings While the genetic antecedents remain incompletely
understood, the treatment armamentarium for EIMs has expanded with new pharmaceutical …
Purpose of Review
Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) represent a complex array of disease processes with variable epidemiologic penetrance, genetic antecedents, and phenotypic presentations. The purpose of this review is to provide an overview of primary and secondary EIMs as well as salient treatment strategies utilized.
Recent Findings
While the genetic antecedents remain incompletely understood, the treatment armamentarium for EIMs has expanded with new pharmaceutical drug classes that effectively treat IBD.
Summary
EIMs are an increasingly recognized complication of IBD that require prompt recognition, multidisciplinary management, and a multifaceted therapeutic approach. This review highlights the complexities and ramifications of EIM management and offers therapeutic guidance.
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