[HTML][HTML] NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis
H Chung, A Vilaysane, A Lau, M Stahl… - Cell Death & …, 2016 - nature.com
… TNFα priming had little-to-no effect on caspase-1 or NLRP3 … co-localization of FADD/TRADD
to NLRP3/ASC/caspase-8-positive … a direct role for NLRP3 in receptor-mediated cell death …
to NLRP3/ASC/caspase-8-positive … a direct role for NLRP3 in receptor-mediated cell death …
[HTML][HTML] Caspase-8-dependent inflammatory responses are controlled by its adaptor, FADD, and necroptosis
B Tummers, L Mari, CS Guy, BL Heckmann… - Immunity, 2020 - cell.com
… -caspase-8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role
of caspase-8 that involves activation of … animals in which caspase-8-mediated apoptosis is …
of caspase-8 that involves activation of … animals in which caspase-8-mediated apoptosis is …
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
J Pang, JE Vince - Seminars in Immunology, 2023 - Elsevier
… domain interactions between FADD and caspase-8 result in … caspase-8, which results in
necroptotic cell death-mediated … -driven transcription of NLRP3 observed in murine myeloid …
necroptotic cell death-mediated … -driven transcription of NLRP3 observed in murine myeloid …
Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
… Both FADD and caspase-8 are involved in mediating the priming and activation of canonical
and atypical NLRP3 … the role of NLRP3 in LPS-induced caspase-8–mediated inflammasome …
and atypical NLRP3 … the role of NLRP3 in LPS-induced caspase-8–mediated inflammasome …
[HTML][HTML] Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4
N Van Opdenbosch, H Van Gorp, M Verdonckt… - Cell reports, 2017 - cell.com
… Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated apoptosis as an …
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 …
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 …
[HTML][HTML] MLKL and FADD are critical for suppressing progressive lymphoproliferative disease and activating the NLRP3 inflammasome
… The in vivo mechanism of RIPK1-RIPK3 necrosome-mediated necroptosis has been
elucidated through intensive genetic studies. Targeted deletion of Fadd or Caspase-8 in mice …
elucidated through intensive genetic studies. Targeted deletion of Fadd or Caspase-8 in mice …
Caspase‐8: not so silently deadly
… on FADD and caspase-8 and occurs independent of the NLRP3 … for caspase-8 in
ripoptosome-mediated, but not canonical, … priming in Ripk3 −/− Caspase-8 −/− macrophages, …
ripoptosome-mediated, but not canonical, … priming in Ripk3 −/− Caspase-8 −/− macrophages, …
[HTML][HTML] Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
… of caspase-8– and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)–mediated …
Additionally, loss of GSDMD promoted robust NLRP3 inflammasome activation. Moreover, …
Additionally, loss of GSDMD promoted robust NLRP3 inflammasome activation. Moreover, …
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
P Orning, E Lien - Journal of Leucocyte Biology, 2021 - academic.oup.com
… As is the case with caspase-8-mediated NLRP3 activation in … inflammasome at the level
of priming, activation, and post-… -FADD-caspase-8 are directly involved in NLRP3 activation …
of priming, activation, and post-… -FADD-caspase-8 are directly involved in NLRP3 activation …
NLRP3 inflammasome activation and cell death
… )-mediated NLRP3 S194 phosphorylation during the priming step is … NLRP3 and caspase-8
in alternative NLRP3 inflammasome … FADD then recruits pro-caspase-8 via the death effector …
in alternative NLRP3 inflammasome … FADD then recruits pro-caspase-8 via the death effector …