… 317 DT40 cells with CtIP S327 mutation resulting in loss of CtIP-… that FEN1 is highly expressed
in a variety of cancers and is … therapeutic target for cancer and 493 autoimmune diseases. …

… ) about the association between the FEN1 and breast cancer risk. The authors indicated that
… to increased risk for developing breast cancer compared with the mutation homozygote [18], …

… However, it is the overexpression of FEN1 in various cancer types that has resulted in it
being … FEN1 mutations in prostate cancer are yet to be explored, however overexpression of …

… of FEN1 in lung cancer cells, we successfully established the A549 FEN1 knockdown stable
… We found that FEN1 knockdown sensitized lung cancer cells to TMZ treatment (Fig. 5B). The …

… of chronic inflammation and cancer [214]. Mutation leading to FEN1 overexpression is a …
TAM signaling components can lead to autoimmunity and a state of chronic inflammation [92,93]…

… The identification of a FEN1 demethylating enzyme would … mutation led to aneuploidy-associated
cancers, which underscores the importance of the gap endonuclease activity of FEN1 …

… The aim of the present review is to identify the effect of mutation that occurred in DNA repair
… pathways may result with genomic instability, genetic disease, cancer, autoimmune, and …

… mutation (in a cancerous gene) results in enhanced growth potential and ultimately induces
tumor. The physical mutants … diseases like cardiovascular diseases, autoimmune disorders, …

… In mice models, the knockout of FEN1 can lead to … cancer cells, FEN1 mutations can result
in reduced nuclease activity (15). Therefore, dysregulated expression of FEN1 resulting from …

… Then, we found that FEN1 rendered the ER+ breast cancer cells insensitive to the growth
inhibitory effects of tamoxifen in vitro, which was associated with the activation of the ERα/…