… was associated with better pancreatic cancer-specific survival. … Solusyklin säätelijä CDK4:n
ja DNA-korjausentsyymi FEN1:n … mutant frequency in human cancers compared with p107 …

… Fen1 exonuclease resulted in cancer initiation and a chronic … in order to induce mutations
driving cancer development. … as cancer, age-related pathologies, autoimmune and chronic …

… consequences of FEN1 deletion, many approaches to understanding FEN1 function, and
its association with cancer in particular, have instead employed FEN1 mutants like E160D and …

… mutation seen in the XPF gene in some patients with XFE progeroid syndrome results in
severe progeroid symptoms without elevated cancer risk 35 . … autoimmune and pro-inflammatory …

… somatic FEN1 mutations are found in human cancers [216]. … develop autoimmunity,
inflammation, and lung cancer late in life… Fen1 mutations result in autoimmunity, chronic …

… Gastric cancer is the fifth most common type of cancer and … to promote decrease of FEN1,
thereby potentially favoring … can result in accumulation of point and frameshift mutations and …

… To test whether the acylation of FEN1 contributed to cell cycle progression, we mutated these
… Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat. Med., 2007, …

… mutations are not independent of one another, we believe studying epigenetic regulation in
the iKC with cSCC mutations is … study the roles of SOD2 and FEN1 in the initiation of RDEB-…

… of FEN1 is associated with lung and gastrointestinal cancers [12,13] and induces various …
resulted from FEN1 catalysis, we determined if the human FEN1 catalytic deficient mutant …

… and autoimmunity [1,88,89]. For instance, … -1 (FEN1) mutant mouse model accumulates
apoptotic-associated cytosolic DNA that forms complex with IgG to promote chronic inflammation […