The adenosine receptor: A homeostatic neuromodulator for fine-tuning control of cognition

JF Chen - The Adenosine Receptors, 2018 - Springer
… of neuromodulation and homeostatic function by adenosine … This perspective led to the
proposal that the adenosine and … : temporally precise interaction of adenosine with dopamine and …

[HTML][HTML] Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

AM Sebastião, JA Ribeiro - Neuropharmacology, 2023 - Elsevier
neuromodulatory action of adenosine has been focusing upon excitatory synapses. Evidence
is growing that GABAergic transmission is also a target for adenosinergic neuromodulation

How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
… this fine-tuning that is most important for the quality of our experience, although this fine-tuning
In fact, besides acting as a neuromodulator, adenosine also fulfills a general homeostatic …

Allosteric Modulation of Adenosine A2A Receptors as a New Therapeutic Avenue

M Korkutata, L Agrawal, M Lazarus - International Journal of Molecular …, 2022 - mdpi.com
… Moreover, the possibility of saturating allosteric effects offers greater potential for fine-tuning
the physiologic response in a positive or negative direction. As allosteric modulators have …

Enhancing spinal cord stimulation-induced pain inhibition by augmenting endogenous adenosine signalling after nerve injury in rats

X Cui, J Liu, A Uniyal, Q Xu, C Zhang, G Zhu… - British journal of …, 2024 - Elsevier
fine-tuning spinal adenosinergic signalling by combining SCS with an adjuvant drug 2′-deoxycoformycin
(dCF) that inhibits the degradation of endogenous adenosineneuromodulation

Therapeutically Fine-Tuning Autonomic Nervous System to Treat Sepsis: A New Perspective on the Immunomodulatory Effects of Acupuncture

Z Zhang, D Zhang, Q Lin, X Cui - Journal of Inflammation Research, 2024 - Taylor & Francis
… Also, other bioagents such as such as adenosine triphosphate … broadly outlined the
neuromodulatory effects of acupuncture … Based on the aforementioned neuromodulatory pattern of …

[HTML][HTML] Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

JF Chen, DS Choi, RA Cunha - Neuropharmacology, 2023 - Elsevier
… and adenosine signaling through multimeric A 2A RD 2 R heterocomplexes allowing a
temporally precise fine-tuning in … The neuromodulation role of adenosine is tightly associated with …

Adenosine A1 receptor activates background potassium channels and modulates information processing in olfactory bulb mitral cells

N Rotermund, S Winandy, T Fischer… - The Journal of …, 2018 - Wiley Online Library
… The study shows for the first time that adenosine influences fine-tuning of the … Neuromodulation
by adenosine is of critical importance in many brain regions, but the role of adenosine in …

Purinergic tuning of the tripartite neuromuscular synapse

C Sousa-Soares, JB Noronha-Matos… - Molecular …, 2023 - Springer
… summarise the modulatory roles of adenosine (ADO) and … their interplay with other
neuromodulatory signalling pathways at … ADO, thus contributing to fine-tuning regulate activation …

Tetanic facilitation of neuromuscular transmission by adenosine A2A and muscarinic M1 receptors is dependent on the uptake of choline via high-affinity transporters

LM Castellão-Santana, P Yumi Abiko, CR Ambiel… - Pharmacology, 2019 - karger.com
fine-tuning controlled by the interplay between pre-synaptic nicotinic, muscarinic and
adenosine … and the muscarinic neuromodulatory control is shifted toward M 2 inhibition [17-20]. …